Area of research
Molecular Biology · Immunology
Research interest
Research interests include NF-κB Signaling Pathways, DNA Repair Mechanisms, Cell death mechanisms and regulation, and Immune Cell Function and Interaction.
Recurrent DNA break clusters drive replication-stress-induced copy number variants and genome diversification
Strand-resolved mutagenicity of DNA damage and repair
Linear interaction between replication and transcription shapes DNA break dynamics at recurrent DNA break Clusters
Rocaglamide breaks TRAIL-resistance in human multiple myeloma and acute T-cell leukemia in vivo in a mouse xenogtraft model
The anticancer phytochemical rocaglamide inhibits Rho GTPase activity and cancer cell migration
Mangrove dolabrane‐type of diterpenes tagalsins suppresses tumor growth <i>via</i><scp>ROS</scp>‐mediated apoptosis and <scp>ATM/ATR–C</scp>hk1/Chk2‐regulated cell cycle arrest
HTLV‐1‐associated adult <scp>T</scp> cell leukemia is highly susceptible to <scp>N</scp>avitoclax due to enhanced <scp>B</scp>ax expression
Targeting CDK9 by wogonin and related natural flavones potentiates the anti‐cancer efficacy of the Bcl‐2 family inhibitor ABT‐263
Tax contributes apoptosis resistance to HTLV-1-infected T cells via suppression of Bid and Bim expression
The natural anticancer compound rocaglamide selectively inhibits the G1-S-phase transition in cancer cells through the ATM/ATR-mediated Chk1/2 cell cycle checkpoints
The Wilms' tumor suppressor WT1 enhances CD95L expression and promotes activation‐induced cell death in leukemic T cells
The Natural Anticancer Compounds Rocaglamides Inhibit the Raf-MEK-ERK Pathway by Targeting Prohibitin 1 and 2
Curcumin Suppresses T Cell Activation by Blocking Ca2+ Mobilization and Nuclear Factor of Activated T Cells (NFAT) Activation