Area of research
Molecular Biology · Radiology, Nuclear Medicine and Imaging
Research interest
Research interests include Protein purification and stability, Monoclonal and Polyclonal Antibodies Research, Crystallization and Solubility Studies, and Protein Structure and Dynamics.
Continuous lyophilization of suspended vials with per-vial inline analytics
Developing ultra-high concentration formulations of human immune globulins for subcutaneous injectables
Mechanistic modeling of lipid nanoparticle formation for the delivery of nucleic acid therapeutics
End-to-end digital twin software for continuous mRNA manufacturing
Machine learning prediction of antibody aggregation and viscosity for high concentration formulation development of protein therapeutics
Machine Learning Applied to Determine the Molecular Descriptors Responsible for the Viscosity Behavior of Concentrated Therapeutic Antibodies
Calculation of therapeutic antibody viscosity with coarse-grained models, hydrodynamic calculations and machine learning-based parameters
Differences in human IgG1 and IgG4 S228P monoclonal antibodies viscosity and self-interactions: Experimental assessment and computational predictions of domain interactions
Molecular computations of preferential interactions of proline, arginine.HCl, and NaCl with IgG1 antibodies and their impact on aggregation and viscosity
Machine Learning Models of Antibody–Excipient Preferential Interactions for Use in Computational Formulation Design
Why We Need Continuous Pharmaceutical Manufacturing and How to Make It Happen
Achieving continuous manufacturing in lyophilization: Technologies and approaches
From Batch to Continuous: Freeze-Drying of Suspended Vials for Pharmaceuticals in Unit-Doses
Understanding the Role of Preferential Exclusion of Sugars and Polyols from Native State IgG1 Monoclonal Antibodies and its Effect on Aggregation and Reversible Self-Association
Molecular Dynamics Analysis of Anti-Agglomerant Surface Adsorption in Natural Gas Hydrates
Regulatory Perspectives on Continuous Pharmaceutical Manufacturing: Moving From Theory to Practice
Core–Shell Composite Hydrogels for Controlled Nanocrystal Formation and Release of Hydrophobic Active Pharmaceutical Ingredients
Lack of a synergistic effect of arginine–glutamic acid on the physical stability of spray-dried bovine serum albumin
Quantitative determination of the surfactant-induced split ratio of influenza virus by fluorescence spectroscopy
Computational tool for the early screening of monoclonal antibodies for their viscosities
Rational design of therapeutic mAbs against aggregation through protein engineering and incorporation of glycosylation motifs applied to bevacizumab
Application of Continuous Crystallization in an Integrated Continuous Pharmaceutical Pilot Plant
End‐to‐End Continuous Manufacturing of Pharmaceuticals: Integrated Synthesis, Purification, and Final Dosage Formation
Use of Continuous MSMPR Crystallization with Integrated Nanofiltration Membrane Recycle for Enhanced Yield and Purity in API Crystallization
End‐to‐End Continuous Manufacturing of Pharmaceuticals: Integrated Synthesis, Purification, and Final Dosage Formation
Fast and scalable purification of a therapeutic full‐length antibody based on process crystallization
Regulating Nucleation Kinetics through Molecular Interactions at the Polymer–Solute Interface
A computational tool to predict the evolutionarily conserved protein–protein interaction hot‐spot residues from the structure of the unbound protein
Protein-Associated Cation Clusters in Aqueous Arginine Solutions and Their Effects on Protein Stability and Size