Area of research
Molecular Biology
Research interest
Research interests include CRISPR and Genetic Engineering, RNA and protein synthesis mechanisms, Advanced biosensing and bioanalysis techniques, and RNA modifications and cancer.
HLTF disrupts Cas9-DNA post-cleavage complexes to allow DNA break processing
RNA-guided RNA silencing by an Asgard archaeal Argonaute
PAM-flexible genome editing with an engineered chimeric Cas9
Hakai is required for stabilization of core components of the m6A mRNA methylation machinery
The oxidoreductase PYROXD1 uses NAD(P)+ as an antioxidant to sustain tRNA ligase activity in pre-tRNA splicing and unfolded protein response
Activation and self-inactivation mechanisms of the cyclic oligoadenylate-dependent CRISPR ribonuclease Csm6
Catalytic Mechanism of Non-Target DNA Cleavage in CRISPR-Cas9 Revealed by <i>Ab Initio</i> Molecular Dynamics
Deciphering Off-Target Effects in CRISPR-Cas9 through Accelerated Molecular Dynamics
Key role of the REC lobe during CRISPR–Cas9 activation by ‘sensing’, ‘regulating’, and ‘locking’ the catalytic HNH domain
CRISPR-Cas9 conformational activation as elucidated from enhanced molecular simulations
Protospacer Adjacent Motif-Induced Allostery Activates CRISPR-Cas9
Striking Plasticity of CRISPR-Cas9 and Key Role of Non-target DNA, as Revealed by Molecular Simulations
A prudent path forward for genomic engineering and germline gene modification
An internal promoter underlies the difference in disease severity between N- and C-terminal truncation mutations of Titin in zebrafish
DNA interrogation by the CRISPR RNA-guided endonuclease Cas9
Structures of Cas9 Endonucleases Reveal RNA-Mediated Conformational Activation
RNA-programmed genome editing in human cells
Evolution of CRISPR RNA recognition and processing by Cas6 endonucleases
Structural mimicry in transcription regulation of human RNA polymerase II by the DNA helicase RECQL5
A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity
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