Area of research
Molecular Biology · Pathology and Forensic Medicine
Research interest
Research interests include Cancer Mechanisms and Therapy, Genomics and Chromatin Dynamics, RNA modifications and cancer, and Melanoma and MAPK Pathways.
RPL22 is a tumor suppressor in MSI-high cancers and a splicing regulator of MDM4
Targeted in silico characterization of fusion transcripts in tumor and normal tissues via FusionInspector
Quantitative Proteomics of the Cancer Cell Line Encyclopedia
Distinct Classes of Complex Structural Variation Uncovered across Thousands of Cancer Genome Graphs
Multiplexed single-cell transcriptional response profiling to define cancer vulnerabilities and therapeutic mechanism of action
Next-generation characterization of the Cancer Cell Line Encyclopedia
The landscape of cancer cell line metabolism
WRN helicase is a synthetic lethal target in microsatellite unstable cancers
Multiplexed single-cell profiling of post-perturbation transcriptional responses to define cancer vulnerabilities and therapeutic mechanism of action
Genetic and transcriptional evolution alters cancer cell line drug response
Targetable vulnerabilities in T- and NK-cell lymphomas identified through preclinical models
Defining a Cancer Dependency Map
Allele-Specific DNA Methylation and Its Interplay with Repressive Histone Marks at Promoter-Mutant TERT Genes
Decomposing Oncogenic Transcriptional Signatures to Generate Maps of Divergent Cellular States
gkmSVM: an R package for gapped-kmer SVM
Pediatric-type nodal follicular lymphoma: a biologically distinct lymphoma with frequent MAPK pathway mutations
Characterizing genomic alterations in cancer by complementary functional associations
Suppression of 19S proteasome subunits marks emergence of an altered cell state in diverse cancers
The Molecular Signatures Database Hallmark Gene Set Collection
Enhanced Regulatory Sequence Prediction Using Gapped k-mer Features
ARID1B is a specific vulnerability in ARID1A-mutant cancers
Locally Disordered Methylation Forms the Basis of Intratumor Methylome Variation in Chronic Lymphocytic Leukemia
Punctuated Evolution of Prostate Cancer Genomes