Area of research
Molecular Medicine · Infectious Diseases
Research interest
Research topics from publications: Characterization of highly virulent community-associated methicillin-resistant Staphylococcus aureus ST9-SCC mec XII causing bloodstream infection in China; Comparative Analysis of Virulence and Toxin Expression of Vancomycin-Intermediate and Vancomycin-Sensitive Staphylococcus aureus Strains. Representative work: strains. Considering its high virulence potential, this strain should be monitored to prevent more widespread dissemination Previous studies on vancomycin-intermediate Staphylococcus aureus (VISA) have been performed largely with respect to investigation of drug resistance, information regarding the of virulence evolution between VISA and VSSA requires further investigation. Here, we compared the virulence and toxin expression of VISA and VSSA strains by using a series of vancomycin-resistant induced S. aureus strains—SA0534, SA0534-V8, and SA0534-V16, and another two pair groups. In this study, we first used the mouse skin infection model to evaluate the invasive capacity of VISA strains. We found that mice infected with VISA had smaller abscess size, and persistent abscess was observed with VISA strains up to 9