Area of research
Molecular Biology · Ophthalmology
Research interest
Research interests include CRISPR and Genetic Engineering, Glaucoma and retinal disorders, Retinal Diseases and Treatments, and Neonatal Respiratory Health Research.
Engineered circular guide RNAs enhance miniature CRISPR/Cas12f-based gene activation and adenine base editing.
hpCasMINI: An engineered hypercompact CRISPR-Cas12f system with boosted gene editing activity.
exoCasMINI: A T5 exonuclease fused CRISPR-Cas12f system with enhanced gene editing efficiency.
METTL3/ALKBH5-Mediated N6-Methyladenosine Modification Drives Macrophage M1 Polarization via the SLC15A3-TASL-IRF5 Signaling Axis in Psoriasis.
Novel insights into the genetic architecture of pregnancy glycemic traits from 14,744 Chinese maternities
Phase-separated DropCRISPRa platform for efficient gene activation in mammalian cells and mice.
Engineered circular guide RNAs boost CRISPR/Cas12a- and CRISPR/Cas13d-based DNA and RNA editing.
Comparison of DNA targeting CRISPR editors in human cells.
Lung adeno-squamous carcinoma modeling using oncogenic KRAS activation in human embryonic stem cell-derived alveolar organoids.
Engineered Cas12a-Plus nuclease enables gene editing with enhanced activity and specificity.
Generation of human embryonic stem cell-derived lung organoids.
Live-cell imaging of genomic loci with Cas9 variants.
Host metabolism dysregulation and cell tropism identification in human airway and alveolar organoids upon SARS-CoV-2 infection.
The role of S-nitrosylation of PFKM in regulation of glycolysis in ovarian cancer cells
SOX9 inactivation affects the proliferation and differentiation of human lung organoids.
The role of S-nitrosylation of PFKM in regulation of glycolysis in ovarian cancer cells.
MiniCAFE, a CRISPR/Cas9-based compact and potent transcriptional activator, elicits gene expression in vivo.
Tag-seq: a convenient and scalable method for genome-wide specificity assessment of CRISPR/Cas nucleases.
Get ready for the CRISPR/Cas system: A beginner's guide to the engineering and design of guide RNAs.
Enhancing site-specific DNA integration by a Cas9 nuclease fused with a DNA donor-binding domain.
Cell-cell contact-induced gene editing/activation in mammalian cells using a synNotch-CRISPR/Cas9 system.
The optimal export tax for a primary commodity in a vertical market
Exchange Rate Pass-Through to Consumer Prices: The Increasing Role of Energy Prices
Long-term Reconstruction of Human Airway Epithelium-like Structure <i>in Vivo</i> with hESCs-derived organoid cells
Engineering macrophages to phagocytose cancer cells by blocking the CD47/SIRPɑ axis.
NOS1 inhibits the interferon response of cancer cells by S-nitrosylation of HDAC2.
Analysis of Chinese pupils’ intents in using bioenergy through the application of structural equation modeling approach
Correction to: Gene activation in human cells using CRISPR/Cpf1-p300 and CRISPR/Cpf1-SunTag systems.
Effect of Key Priority Forestry Programs on off-farm employment: Evidence from Chinese rural households