Area of research
Molecular Biology · Pharmacology
Research interest
Jay Keasling is the Philomathia Distinguished Chair in Alternative Energy and a Professor of Chemical & Biomolecular Engineering and of Bioengineering. The research in the Keasling Laboratory focuses on the metabolic engineering of microorganisms for the environmentally friendly synthesis of biofuels, commodity and specialty chemicals, and pharmaceuticals. To that end, they have developed a number of new genetic and mathematical tools to allow more precise and reproducible control of metabolism. These tools are being used in such applications as synthesis of biodegradable polymers, biofuels, flavors and fragrances, and pharmaceuticals.
Growth-coupled reverse β-oxidation enables redox-balanced fatty-alcohol fermentation and strain evolution
Techno-economic assessment-guided biofoundry for microbial strain development.
Influence of titer, rate, yield, and scale on the cost and life-cycle emissions of biomanufacturing.
A biosynthetic survey of hypocrealean biocontrol fungi.
Author Correction: A polyketide-based biosynthetic platform for diols, amino alcohols and hydroxy acids
Binary vector copy number engineering improves Agrobacterium-mediated transformation.
Fast growth and high-titer bioproduction from renewable formate via metal-dependent formate dehydrogenase in Escherichia coli
A polyketide-based biosynthetic platform for diols, amino alcohols and hydroxy acids
Retrobiosynthesis of unnatural lactams via reprogrammed polyketide synthase
Partnerships with Indigenous Peoples for an ethical bioeconomy
Machine learning-led semi-automated medium optimization reveals salt as key for flaviolin production in Pseudomonas putida.
Fast growth and high-titer bioproduction from renewable formate via metal-dependent formate dehydrogenase in Escherichia coli.
Partnerships with Indigenous Peoples for an ethical bioeconomy.
Automated Strain Construction for Biosynthetic Pathway Screening in Yeast.
Labels as a feature: Network homophily for systematically annotating human GPCR drug-target interactions.
Engineering controllable alteration of malonyl-CoA levels to enhance polyketide production.
Engineering Polyketide Stereocenters with Ketoreductase Domain Exchanges.
Leveraging a synthetic biology approach to enhance BCG-mediated expansion of Vγ9Vδ2 T cells
Black yeasts are efficient heterologous hosts of a wide range of fungal polyketides
Hyaluronan Ameliorates Viral Pneumonia in Mice and Humans by Inhibiting Transcription Factor E2F1
RB-TnSeq elucidates dicarboxylic-acid-specific catabolism in β-proteobacteria for improved plastic monomer upcycling.
Advances in the microbial biosynthesis of therapeutic terpenoids.
The mevalonate pathway of isoprenoid biosynthesis supports metabolic flexibility in <i>Mycobacterium marinum</i>.
RB-TnSeq elucidates dicarboxylic acid specific catabolism in β-proteobacteria for improved plastic monomer upcycling
A highly active Burkholderia polyketoacyl-CoA thiolase for production of triacetic acid lactone.
Enzymology and Structural Basis of Glycosyltransferases Involved in Saponin C28 Carboxylic Acid <i>O</i>‑d‑Fucosylation.
Author Correction: Binary vector copy number engineering improves Agrobacterium-mediated transformation.
Merging the computational design of chimeric type I polyketide synthases with enzymatic pathways for chemical biosynthesis.
Author Correction: Machine learning-led semi-automated medium optimization reveals salt as key for flaviolin production in Pseudomonas putida.
A biosynthetic survey of biocontrol fungi
Expanding protein sequence space beyond the bounds of evolution: Polyketide synthase-driven biosynthesis of designer amino acids
FMRG: Digital Light Manufacturing for the Circular Economy
Physical regulation of cellular respiration by membrane lipid composition
Indo-US Workshop on "Cell Factories" to be held in Mumbai, India
Design Principles for Engineering Biology - Hyatt Regency, Tysons, VA - November 11 & 12, 2015
ERASynBio: Synthetic biochemical pathways for efficient production of novel biofuels (SynPath)
Investigation of terminal alkene formation by polyketide synthases and the application toward sustainable alpha-olefin production
Synthetic Biology of Yeast
Collaborative Research: Exploiting the Syntegron Technology Platform for Assembly and 0ptimisation of Complex Genetic Ensembles
Collaborative Research: Synthetic integrons for continuous directed evolution of complex genetic ensembles
ARS Synthetica - A Multimedia Forum Exploring the Artful Design of Living Things
Synthetic Biology Engineering Research Center (SynBERC)
Laboratory evolution of mRNA stability
Biochemical Engineering XII
Engineering mRNA Stability for Coordinated Expression of Multiple Genes in New Operons
ME: Metabolic Engineering of Isoprenoid Production
ME: Strategies for Metabolic Engineering of Environmental Microorganisms - Applications to Degradation of Organophosphate Contaminants
CAREER: Strategies for Metabolic Engineering of Bacteria: Novel Synthesis of Biodegradable Polymers
Research Initiation Award: Design of Auxiliary Chromosomes for Escherichia coli