Area of research
Cancer Research · Molecular Biology
Research interest
Research interests include Biology, Cell biology, Cancer research, Phosphorylation, Cancer, and Warburg effect.
ADSL-generated fumarate binds and inhibits STING to promote tumour immune evasion
ADSL promotes autophagy and tumor growth through fumarate-mediated Beclin1 dimethylation
PSAT1 impairs ferroptosis and reduces immunotherapy efficacy via GPX4 hydroxylation
PCK1 inhibits cGAS-STING activation by consumption of GTP to promote tumor immune evasion
ACSS2 acts as a lactyl-CoA synthetase and couples KAT2A to function as a lactyltransferase for histone lactylation and tumor immune evasion
A chimeric peptide promotes immune surveillance of senescent cells in injury, fibrosis, tumorigenesis and aging
Creatine kinase B suppresses ferroptosis by phosphorylating GPX4 through a moonlighting function
A century of the Warburg effect
Nucleus-exported CLOCK acetylates PRPS to promote de novo nucleotide synthesis and liver tumour growth
Pan-cancer tRNA-derived fragment CAT1 coordinates RBPMS to stabilize NOTCH2 mRNA to promote tumorigenesis
UBC9 stabilizes PFKFB3 to promote aerobic glycolysis and proliferation of glioblastoma cells
Regulation of gene expression by glycolytic and gluconeogenic enzymes
Fructose-1,6-bisphosphatase 1 functions as a protein phosphatase to dephosphorylate histone H3 and suppresses PPARα-regulated gene transcription and tumour growth
Iguratimod Restrains Circulating Follicular Helper T Cell Function by Inhibiting Glucose Metabolism via Hif1α-HK2 Axis in Rheumatoid Arthritis
Cancer metabolism and tumor microenvironment: fostering each other?
Lipid metabolism and cancer
Nuclear PGK1 Alleviates ADP-Dependent Inhibition of CDC7 to Promote DNA Replication
KAT2A coupled with the α-KGDH complex acts as a histone H3 succinyltransferase
Nucleus-Translocated ACSS2 Promotes Gene Transcription for Lysosomal Biogenesis and Autophagy
Stabilization of phosphofructokinase 1 platelet isoform by AKT promotes tumorigenesis
Mitochondria-Translocated PGK1 Functions as a Protein Kinase to Coordinate Glycolysis and the TCA Cycle in Tumorigenesis
A splicing switch from ketohexokinase-C to ketohexokinase-A drives hepatocellular carcinoma formation
Regulatory circuit of PKM2/NF-κB/miR-148a/152-modulated tumor angiogenesis and cancer progression
Protein Tyrosine Phosphatase-PEST and β8 Integrin Regulate Spatiotemporal Patterns of RhoGDI1 Activation in Migrating Cells
Targeting aPKC disables oncogenic signaling by both the EGFR and the proinflammatory cytokine TNFα in glioblastoma
ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect
EGFR-Induced and PKCε Monoubiquitylation-Dependent NF-κB Activation Upregulates PKM2 Expression and Promotes Tumorigenesis