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Rehana K. Leak

Duquesne University · US
Area of research
Neurology · Developmental Neuroscience
Research interest
Research interests include Neuroinflammation and Neurodegeneration Mechanisms, Parkinson's Disease Mechanisms and Treatments, Neurological Disease Mechanisms and Treatments, and Neurogenesis and neuroplasticity mechanisms.
h-index
62
citations
16,749
works
196
NIH funding
primary concept
email

Recent publications

Enhancing and Extending Biological Performance and Resilience
Dose-Response 2018cited by 104position: firstdoi
Peroxisome proliferator-activated receptor γ (PPARγ): A master gatekeeper in CNS injury and repair
Progress in Neurobiology 2017cited by 225position: middledoi
ST2/IL-33-Dependent Microglial Response Limits Acute Ischemic Brain Injury
Journal of Neuroscience 2017cited by 211position: middledoi
Regulatory T cells ameliorate tissue plasminogen activator-induced brain haemorrhage after stroke
Brain 2017cited by 179position: middledoi
Endothelium-targeted overexpression of heat shock protein 27 ameliorates blood–brain barrier disruption after ischemic brain injury
Proceedings of the National Academy of Sciences 2017cited by 158position: middledoi
Fast free-of-acrylamide clearing tissue (FACT)—an optimized new protocol for rapid, high-resolution imaging of three-dimensional brain tissue
Scientific Reports 2017cited by 48position: middledoi
Rapid endothelial cytoskeletal reorganization enables early blood–brain barrier disruption and long-term ischaemic reperfusion brain injury
Nature Communications 2016cited by 425position: middledoi
Interleukin-4 Is Essential for Microglia/Macrophage M2 Polarization and Long-Term Recovery After Cerebral Ischemia
Stroke 2016cited by 424position: middledoi
Omega-3 polyunsaturated fatty acids mitigate blood–brain barrier disruption after hypoxic–ischemic brain injury
Neurobiology of Disease 2016cited by 86position: middledoi
APE1/Ref-1 facilitates recovery of gray and white matter and neurological function after mild stroke injury
Proceedings of the National Academy of Sciences 2016cited by 62position: middledoi
HDAC inhibition prevents white matter injury by modulating microglia/macrophage polarization through the GSK3β/PTEN/Akt axis
Proceedings of the National Academy of Sciences 2015cited by 394position: middledoi
White matter injury and microglia/macrophage polarization are strongly linked with age-related long-term deficits in neurological function after stroke
Experimental Neurology 2015cited by 187position: middledoi
Rosiglitazone Promotes White Matter Integrity and Long-Term Functional Recovery After Focal Cerebral Ischemia
Stroke 2015cited by 153position: middledoi
Demyelination as a rational therapeutic target for ischemic or traumatic brain injury
Experimental Neurology 2015cited by 151position: middledoi
Dietary supplementation with omega-3 polyunsaturated fatty acids robustly promotes neurovascular restorative dynamics and improves neurological functions after stroke
Experimental Neurology 2015cited by 55position: middledoi
Microglial and macrophage polarization—new prospects for brain repair
Nature Reviews Neurology 2014cited by 1,467position: middledoi
Molecular dialogs between the ischemic brain and the peripheral immune system: Dualistic roles in injury and repair
Progress in Neurobiology 2014cited by 200position: middledoi
Omega-3 Fatty Acids Protect the Brain against Ischemic Injury by Activating Nrf2 and Upregulating Heme Oxygenase 1
Journal of Neuroscience 2014cited by 177position: middledoi
n-3 PUFA supplementation benefits microglial responses to myelin pathology
Scientific Reports 2014cited by 140position: middledoi
Neurobiology of microglial action in CNS injuries: Receptor-mediated signaling mechanisms and functional roles
Progress in Neurobiology 2014cited by 132position: middledoi
Splenic Responses in Ischemic Stroke: New Insights into Stroke Pathology
CNS Neuroscience & Therapeutics 2014cited by 65position: middledoi
Neuronal NAMPT is Released after Cerebral Ischemia and Protects against White Matter Injury
Journal of Cerebral Blood Flow & Metabolism 2014cited by 62position: middledoi
Ethyl Pyruvate Protects against Blood–Brain Barrier Damage and Improves Long‐term Neurological Outcomes in a Rat Model of Traumatic Brain Injury
CNS Neuroscience & Therapeutics 2014cited by 58position: middledoi
Microglia/Macrophage Polarization Dynamics in White Matter after Traumatic Brain Injury
Journal of Cerebral Blood Flow & Metabolism 2013cited by 484position: middledoi
Omega-3 Polyunsaturated Fatty Acid Supplementation Improves Neurologic Recovery and Attenuates White Matter Injury after Experimental Traumatic Brain Injury
Journal of Cerebral Blood Flow & Metabolism 2013cited by 131position: middledoi
Adoptive Regulatory T-Cell Therapy Preserves Systemic Immune Homeostasis After Cerebral Ischemia
Stroke 2013cited by 101position: middledoi
HSP27 Protects the Blood-Brain Barrier Against Ischemia-Induced Loss of Integrity
CNS & Neurological Disorders - Drug Targets 2013cited by 52position: firstdoi
Microglia/Macrophage Polarization Dynamics Reveal Novel Mechanism of Injury Expansion After Focal Cerebral Ischemia
Stroke 2012cited by 1,567position: middledoi
Emerging roles of Nrf2 and phase II antioxidant enzymes in neuroprotection
Progress in Neurobiology 2012cited by 599position: middledoi
Scriptaid, a Novel Histone Deacetylase Inhibitor, Protects Against Traumatic Brain Injury via Modulation of PTEN and AKT Pathway
Neurotherapeutics 2012cited by 104position: middledoi

Grants

No grants ingested yet.

Frequent collaborators

Jun Chen · Kaiser Permanente26 papers (2012–2017)Yanqin Gao · Allen Institute for Brain Science24 papers (2012–2017)Xiaoming Hu · University of Pittsburgh24 papers (2012–2017)Yejie Shi · University of Pittsburgh13 papers (2014–2017)Hongjian Pu · University of Pittsburgh9 papers (2012–2017)R. Anne Stetler · University of Pittsburgh7 papers (2013–2017)Leilei Mao · Central South University7 papers (2013–2017)Peiying Li · Nanyang Institute of Technology7 papers (2012–2017)Feng Zhang · Qingdao University6 papers (2012–2016)Guohua Wang · Qingdao University6 papers (2012–2015)Anthony K. F. Liou · Singapore General Hospital5 papers (2012–2014)Wei Cai · Sun Yat-sen University5 papers (2015–2017)Wenting Zhang · Changzhi University5 papers (2012–2017)Chengrui An · Fudan University5 papers (2012–2015)Xiaoyan Jiang · Tongji University5 papers (2012–2017)Guodong Cao · Fudan University4 papers (2012–2016)Michael V. L. Bennett · Fudan University4 papers (2015–2017)Jun Suenaga · Yokohama City University4 papers (2014–2015)Zhongfang Weng · Fudan University4 papers (2012–2016)Meijuan Zhang · Hebei University of Science and Technology3 papers (2012–2014)