Area of research
Molecular Biology · Oncology
Research interest
Research interests include Ubiquitin and proteasome pathways, Protein Degradation and Inhibitors, Peptidase Inhibition and Analysis, and Glycosylation and Glycoproteins Research.
Structure-Based Design of Pan-Selective Peptide Epoxyketones for the Three Human Immunoproteasome Active Sites.
Carfilzomib-specific proteasome β5/β2 inhibition drives cardiotoxicity via remodeling of protein homeostasis and the renin-angiotensin-system.
Phosphate ions modulate enzyme activity and epistatic effects in two clavulanic acid-resistant β-lactamase mutants.
CellEKT: A Robust Chemical Proteomics Workflow to Profile Cellular Target Engagement of Kinase Inhibitors.
Using BONCAT to dissect the proteome of <i>S. aureus</i> persisters.
A Highly Specific Monoacylglycerol Lipase PROTAC Probe
Human milk oligosaccharide 2'-fucosyllactose protects against high-fat diet-induced obesity by changing intestinal mucus production, composition and degradation linked to changes in gut microbiota and faecal proteome profiles in mice.
Immunoproteasomal Inhibition With ONX-0914 Attenuates Atherosclerosis and Reduces White Adipose Tissue Mass and Metabolic Syndrome in Mice.
The proteasome modulates endocytosis specifically in glomerular cells to promote kidney filtration.
Previously Published Phosphatase Probes have Limited Utility Due to their Unspecific Reactivity.
CellEKT: A robust chemical proteomics workflow to profile cellular target engagement of kinase inhibitors
Probing the metalloproteome: an 8-mercaptoquinoline motif enriches minichromosome maintenance complex components as significant metalloprotein targets in live cells.
A monoacylglycerol lipase inhibitor showing therapeutic efficacy in mice without central side effects or dependence.
Chemical Proteomics Reveals Antibiotic Targets of Oxadiazolones in MRSA.
Non-functional ubiquitin C-terminal hydrolase L1 drives podocyte injury through impairing proteasomes in autoimmune glomerulonephritis.
High-dose carfilzomib achieves superior anti-tumor activity over low-dose and recaptures response in relapsed/refractory multiple myeloma resistant to lowdose carfilzomib by co-inhibiting the β2 and β1 subunits of the proteasome complex.
The development of a broad-spectrum retaining β-exo-galactosidase activity-based probe.
Bioorthogonal Peptide Enrichment from Complex Samples Using a Rink-Amide-Based Catch-and-Release Strategy.
Comparative Photoaffinity Profiling of Omega-3 Signaling Lipid Probes Reveals Prostaglandin Reductase 1 as a Metabolic Hub in Human Macrophages.
A Chemical Biological Approach to Study G Protein-Coupled Receptors: Labeling the Adenosine A<sub>1</sub> Receptor Using an Electrophilic Covalent Probe.
Chemical Proteomics Reveals Off-Targets of the Anandamide Reuptake Inhibitor WOBE437.
Synthesis of broad-specificity activity-based probes for <i>exo</i>-β-mannosidases.
Platelet EVs contain an active proteasome involved in protein processing for antigen presentation via MHC-I molecules
Platelet EVs contain an active proteasome involved in protein processing for antigen presentation via MHC-I molecules.
Activity-Based Protein Profiling of Retaining α-Amylases in Complex Biological Samples.
Immunoediting role for major vault protein in apoptotic signaling induced by bacterial <i>N</i>-acyl homoserine lactones.
Treatment with HIV-Protease Inhibitor Nelfinavir Identifies Membrane Lipid Composition and Fluidity as a Therapeutic Target in Advanced Multiple Myeloma
Bioorthogonal protein labelling enables the study of antigen processing of citrullinated and carbamylated auto-antigens.
Development of Non-Hydrolysable Oligosaccharide Activity-Based Inactivators for Endoglycanases: A Case Study on α-1,6 Mannanases.
Correction: Glycosylated cyclophellitol-derived activity-based probes and inhibitors for cellulases.