Area of research
Genetics · Psychiatry and Mental health
Research interest
I completed undergraduate medical training at University College Cork in 1993 and Membership of the Royal College of Psychiatrists (UK) in 1998. I was awarded a Wellcome Trust Research Training Fellowship in Mental Health in 2000 to develop my interest in the genetic etiology of psychosis and founded the Psychosis Research Group (www.medicine.tcd.ie/neuropsychiatric-â€genetics/psychosis/). I was appointed Senior Lecturer in Psychiatry at TCD (now Professor) and Consultant Psychiatrist at St James's Hospital, Dublin in 2006. Since its inception my research group's goal has been to identify and investigate genetic mechanisms of psychosis, to define molecular etiology, and to use this information to serve patients by improving diagnostics and developing new therapeutic approaches.
A disease-specific convergence of host and Epstein–Barr virus genetics in multiple sclerosis
Fine-mapping genomic loci refines bipolar disorder risk genes
The Psychiatric Genomics Consortium: discoveries and directions
Exploring penetrance of clinically relevant variants in over 800,000 humans from the Genome Aggregation Database
Profiling brain morphology for autism spectrum disorder with two cross-culture large-scale consortia
Brain charts for the human lifespan
Rare coding variants in ten genes confer substantial risk for schizophrenia
Exome sequencing in bipolar disorder identifies AKAP11 as a risk gene shared with schizophrenia
Interaction Testing and Polygenic Risk Scoring to Estimate the Association of Common Genetic Variants With Treatment Resistance in Schizophrenia
Graph Convolutional Networks Reveal Network-Level Functional Dysconnectivity in Schizophrenia
Publisher Correction: Brain charts for the human lifespan
A Comparison of Ten Polygenic Score Methods for Psychiatric Disorders Applied Across Multiple Cohorts
DNA methylation meta-analysis reveals cellular alterations in psychosis and markers of treatment-resistant schizophrenia
A <scp>meta‐analysis</scp> of deep brain structural shape and asymmetry abnormalities in 2,833 individuals with schizophrenia compared with 3,929 healthy volunteers via the <scp>ENIGMA Consortium</scp>
Characterisation of age and polarity at onset in bipolar disorder
Identifying nootropic drug targets via large-scale cognitive GWAS and transcriptomics
Neuroharmony: A new tool for harmonizing volumetric MRI data from unseen scanners
Functional Magnetic Resonance Imaging Connectivity Accurately Distinguishes Cases With Psychotic Disorders From Healthy Controls, Based on Cortical Features Associated With Brain Network Development
Sex-Dependent Shared and Non-Shared Genetic Architecture Across Mood and Psychotic Disorders
Methyl-CpG-binding protein 2 mediates overlapping mechanisms across brain disorders
Identifying Nootropic Drug Targets via Large-Scale Cognitive GWAS and Transcriptomics
Deficit not bias: A quantifiable neuropsychological model of delusions
Cortical patterning of abnormal morphometric similarity in psychosis is associated with brain expression of schizophrenia-related genes
Pleiotropic Meta-Analysis of Cognition, Education, and Schizophrenia Differentiates Roles of Early Neurodevelopmental and Adult Synaptic Pathways
The Relationship Between Polygenic Risk Scores and Cognition in Schizophrenia
Detecting schizophrenia at the level of the individual: relative diagnostic value of whole-brain images, connectome-wide functional connectivity and graph-based metrics
Integrating machining learning and multimodal neuroimaging to detect schizophrenia at the level of the individual
Association of Copy Number Variation of the 15q11.2 BP1-BP2 Region With Cortical and Subcortical Morphology and Cognition
Pleiotropic Meta-Analysis of Cognition, Education, and Schizophrenia Differentiates Roles of Early Neurodevelopmental and Adult Synaptic Pathways
Correction: Dose response of the 16p11.2 distal copy number variant on intracranial volume and basal ganglia