Area of research
Immunology · Radiology, Nuclear Medicine and Imaging
Research interest
Natural killer (NK) cells are a type of white blood cell that provides protection against microbial pathogens and tumors. Since the early 1980’s, our lab has investigated how NK cells distinguish between normal healthy cells and cells that are transformed or infected with viruses. NK cells express a diverse array of inhibitory and activating receptors on their cells surface that bind to ligands expressed on the cell surface of potential target cells.
Author Reply to Peer Reviews of Natural Killer Cell Receptor Signaling and Activation Depend on Cell Cycle Stages
SYK negatively regulates ITAM-mediated human NK cell signaling and CD19-CAR NK cell efficacy
SYK negatively regulates ITAM-mediated human NK cell signaling and CD19-CAR NK cell efficacy.
High-affinity CD16A polymorphism associated with reduced risk ofsevere COVID-19
CITE-Seq Analysis Reveals a Differential Natural Killer Cell <i>SPON2</i> Expression in Cardiovascular Disease Patients Impacted by Human-Cytomegalovirus Serostatus and Diabetes.
FcɛR1γ-based activating chimeric antigen receptor enhanced natural killer cell function against HLA-E+ cells
FcɛR1γ-based Activating Chimeric Antigen Receptors enhanced Natural Killer cell function against HLA-E <sup>+</sup> cells
High-affinity CD16A polymorphism associated with reduced risk ofsevere COVID-19
Natural Killer Cell Receptor Signaling and Activation Depend on Cell Cycle Stages
Site-specific genome engineering of primary human natural killer cells for programmable anti-tumor function
CITE-Seq Analysis Reveals a Differential Natural Killer Cell SPON2 Expression in Cardiovascular Disease Patients Impacted by Human-Cytomegalovirus Serostatus and Diabetes. Int J Mol Sci. 2025 Feb 06; 26(3).
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High-dimensional single-cell analysis of human natural killer cell heterogeneity
High-dimensional single-cell analysis of human natural killer cell heterogeneity.
Hypoimmune induced pluripotent stem cells survive long term in fully immunocompetent, allogeneic rhesus macaques.
Five decades of natural killer cell discovery
Pretreatment with IL-15 and IL-18 rescues natural killer cells from granzyme B-mediated apoptosis after cryopreservation
Five decades of natural killer cell discovery.
<scp>ITAM</scp>‐based receptors in natural killer cells
ITAM-based receptors in natural killer cells.
PVRL2 Suppresses Antitumor Immunity through PVRIG- and TIGIT-independent Pathways.
Spleen Tyrosine Kinase (SYK) negatively regulates ITAM-mediated human NK cell signaling and CD19-CAR NK cell efficacy
Table S1 from PVRL2 Suppresses Antitumor Immunity through PVRIG- and TIGIT-independent Pathways
Figure S3 from PVRL2 Suppresses Antitumor Immunity through PVRIG- and TIGIT-independent Pathways
Data from PVRL2 Suppresses Antitumor Immunity through PVRIG- and TIGIT-independent Pathways
Figure S1 from PVRL2 Suppresses Antitumor Immunity through PVRIG- and TIGIT-independent Pathways
Figure S3 from PVRL2 Suppresses Antitumor Immunity through PVRIG- and TIGIT-independent Pathways
Data from PVRL2 Suppresses Antitumor Immunity through PVRIG- and TIGIT-independent Pathways
High-Dimensional Single-Cell Analysis of Natural Killer Cell Heterogeneity in Human Blood
Figure S1 from PVRL2 Suppresses Antitumor Immunity through PVRIG- and TIGIT-independent Pathways
Figure S2 from PVRL2 Suppresses Antitumor Immunity through PVRIG- and TIGIT-independent Pathways