Area of research
Infectious Diseases · Physiology
Research interest
Research interests include Tuberculosis Research and Epidemiology, Nitric Oxide and Endothelin Effects, Mycobacterium research and diagnosis, and Immune Response and Inflammation.
Candidate transmission survival genome of <i>Mycobacterium tuberculosis</i>
Interferon- <b>γ</b> and infectious diseases: Lessons and prospects
Tuberculosis in otherwise healthy adults with inherited TNF deficiency
Type I interferon exacerbates Mycobacterium tuberculosis induced human macrophage death
Dual-pharmacophore artezomibs hijack the Plasmodium ubiquitin-proteasome system to kill malaria parasites while overcoming drug resistance
Nonresolving inflammation redux
The Tuberculosis Drug Accelerator at year 10: what have we learned?
Multiform antimicrobial resistance from a metabolic mutation
Oxidative damage and delayed replication allow viable <i>Mycobacterium tuberculosis</i> to go undetected
Macrocyclic Peptides that Selectively Inhibit the <i>Mycobacterium tuberculosis</i> Proteasome
Whole Cell Active Inhibitors of Mycobacterial Lipoamide Dehydrogenase Afford Selectivity over the Human Enzyme through Tight Binding Interactions
Biology of antimicrobial resistance and approaches to combat it
Resisting antimicrobial resistance
Type I interferon signaling mediates <i>Mycobacterium tuberculosis</i>–induced macrophage death
Neutrophils and COVID-19: Nots, NETs, and knots
Fatal Cytomegalovirus Infection in an Adult with Inherited NOS2 Deficiency
Nonredundant functions of <i>Mycobacterium tuberculosis</i> chaperones promote survival under stress
Opposing reactions in coenzyme A metabolism sensitize <i>Mycobacterium tuberculosis</i> to enzyme inhibition
Antimalarial proteasome inhibitor reveals collateral sensitivity from intersubunit interactions and fitness cost of resistance
ATP hydrolysis-coupled peptide translocation mechanism of <i>Mycobacterium tuberculosis</i> ClpB
Targeting Phenotypically Tolerant <i>Mycobacterium tuberculosis</i>
Rifamycin action on RNA polymerase in antibiotic-tolerant <i>Mycobacterium tuberculosis</i> results in differentially detectable populations
Distinct Spatiotemporal Dynamics of Peptidoglycan Synthesis between <i>Mycobacterium smegmatis</i> and <i>Mycobacterium tuberculosis</i>
<i>N</i> -methylation of a bactericidal compound as a resistance mechanism in <i>Mycobacterium tuberculosis</i>
Stressed Mycobacteria Use the Chaperone ClpB to Sequester Irreversibly Oxidized Proteins Asymmetrically Within and Between Cells
E1 of α-ketoglutarate dehydrogenase defends <i>Mycobacterium tuberculosis</i> against glutamate anaplerosis and nitroxidative stress
Cooperative development of antimicrobials: looking back to look ahead
Antibiotic Resistance — Problems, Progress, and Prospects
Isocitrate lyase mediates broad antibiotic tolerance in Mycobacterium tuberculosis