Area of research
Infectious Diseases · Animal Science and Zoology
Research interest
Research interests include SARS-CoV-2 and COVID-19 Research, COVID-19 Clinical Research Studies, Animal Virus Infections Studies, and SARS-CoV-2 detection and testing.
Recurrent SARS-CoV-2 Omicron broadly neutralizing humanized antibodies in different single human V <sub>H</sub> 1-2-rearranging mouse models
Recurrent SARS-CoV-2 Omicron broadly neutralizing humanized antibodies in different single human V<sub>H</sub>1-2-rearranging mouse models.
Antibody cocktails based on the occupationally acquired immunity of pediatricians neutralize and confer protection against RSV and hMPV.
Evolving antibody response to SARS-CoV-2 antigenic shift from XBB to JN.1.
Viral evolution prediction identifies broadly neutralizing antibodies to existing and prospective SARS-CoV-2 variants.
Deciphering SARS-CoV-2 evolution under antibody immune pressure.
SARS-CoV-2 keeps evolving, so must our research efforts.
Safety, tolerability, and pharmacokinetics of anti-SARS-CoV-2 monoclonal antibody SA55 injection in healthy participants.
Repeated Omicron exposures override ancestral SARS-CoV-2 immune imprinting.
Conversion of monoclonal IgG to dimeric and secretory IgA restores neutralizing ability and prevents infection of Omicron lineages
Conversion of monoclonal IgG to dimeric and secretory IgA restores neutralizing ability and prevents infection of Omicron lineages.
Structural and molecular basis of the epistasis effect in enhanced affinity between SARS-CoV-2 KP.3 and ACE2.
Deletion of V483 in the spike confers evolutionary advantage on SARS-CoV-2 for human adaptation and host-range expansion after a prolonged pandemic.
The delivery device of SARS-CoV-2 mucosal vaccine matters.
Imprinted SARS-CoV-2 humoral immunity induces convergent Omicron RBD evolution.
Fast evolution of SARS-CoV-2 BA.2.86 to JN.1 under heavy immune pressure
ACE2 binding and antibody evasion in enhanced transmissibility of XBB.1.5.
Repeated Omicron exposures override ancestral SARS-CoV-2 immune imprinting
Convergent evolution of SARS-CoV-2 XBB lineages on receptor-binding domain 455-456 synergistically enhances antibody evasion and ACE2 binding.
Immune evasion and ACE2 binding affinity contribute to SARS-CoV-2 evolution.
Single-cell bisulfite-free 5mC and 5hmC sequencing with high sensitivity and scalability.
Safety and Effectiveness of SA58 Nasal Spray Against COVID-19 Infection in Medical Personnel: An Open-Label, Blank-Controlled Study - Hohhot City, Inner Mongolia Autonomous Region, China, 2022.
Post-Exposure Prophylaxis with SA58 (anti-COVID-19 monoclonal antibody) Nasal Spray for the prevention of symptomatic Coronavirus Disease 2019 in healthy adult workers: A randomized, single-blind, placebo-controlled clinical study
Omicron escapes the majority of existing SARS-CoV-2 neutralizing antibodies.
BA.2.12.1, BA.4 and BA.5 escape antibodies elicited by Omicron infection.
Circular RNA vaccines against SARS-CoV-2 and emerging variants
Circular RNA vaccines against SARS-CoV-2 and emerging variants.
Structural and functional characterizations of infectivity and immune evasion of SARS-CoV-2 Omicron
Characterization of the enhanced infectivity and antibody evasion of Omicron BA.2.75.
Rational identification of potent and broad sarbecovirus-neutralizing antibody cocktails from SARS convalescents.