Area of research
Infectious Diseases · Virology
Research interest
Research interests include HIV Research and Treatment, SARS-CoV-2 and COVID-19 Research, Monoclonal and Polyclonal Antibodies Research, and vaccines and immunoinformatics approaches.
An engineered immunogen activates diverse HIV broadly neutralizing antibody precursors and promotes acquisition of improbable mutations.
Conformational trajectory of the HIV-1 fusion peptide during CD4-induced envelope opening.
Nonstabilized SARS-CoV-2 spike mRNA vaccination induces broadly neutralizing antibodies in nonhuman primates.
An integrated workflow for structural virology with a 100 keV electron microscope
Structural determination of the HIV-1 Variable Region 3 epitope of antibody 19b
Vaccine induction of heterologous HIV-1-neutralizing antibody B cell lineages in humans
SARS-CoV-2 Omicron XBB lineage spike structures, conformations, antigenicity, and receptor recognition.
Conformational flexibility of HIV-1 envelope glycoproteins modulates transmitted/founder sensitivity to broadly neutralizing antibodies.
Microsecond dynamics control the HIV-1 Envelope conformation
Microsecond dynamics control the HIV-1 Envelope conformation.
Engineering immunogens that select for specific mutations in HIV broadly neutralizing antibodies
Structural Studies of Henipavirus Glycoproteins.
SARS-CoV-2 Omicron XBB lineage spike structures, conformations, antigenicity, and receptor recognition
Conformational trajectory of the HIV-1 fusion peptide during CD4-induced envelope opening
Evolution of the SARS-CoV-2 Omicron spike.
Structural basis for breadth development in the HIV-1 V3-glycan targeting DH270 antibody clonal lineage.
Vaccine Induction of Heterologous HIV-1 Neutralizing Antibody B Cell Lineages in Humans
Structures of Langya virus fusion protein ectodomain in pre and post fusion conformation
Structural diversity of the SARS-CoV-2 Omicron spike.
A broadly cross-reactive antibody neutralizes and protects against sarbecovirus challenge in mice.
Cryo-EM structures of SARS-CoV-2 Omicron BA.2 spike.
Stabilized HIV-1 envelope immunization induces neutralizing antibodies to the CD4bs and protects macaques against mucosal infection.
Transient transfection and purification of SARS-CoV-2 spike protein from mammalian cells.
Cryo-EM structures of SARS-CoV-2 Omicron BA.2 spike
Effect of natural mutations of SARS-CoV-2 on spike structure, conformation, and antigenicity.
In vitro and in vivo functions of SARS-CoV-2 infection-enhancing and neutralizing antibodies
D614G Spike Mutation Increases SARS CoV-2 Susceptibility to Neutralization.
D614G Mutation Alters SARS-CoV-2 Spike Conformation and Enhances Protease Cleavage at the S1/S2 Junction.
Neutralizing antibody vaccine for pandemic and pre-emergent coronaviruses.
Fab-dimerized glycan-reactive antibodies are a structural category of natural antibodies.