Jianjun Lv

Area of research

Molecular Biology · Geriatrics and Gerontology

Research interest

Research topics from publications: Targeted inhibition of STAT3 as a potential treatment strategy for atherosclerosis; Focusing on claudin-5: A promising candidate in the regulation of BBB to treat ischemic stroke; PGC-1: The Energetic Regulator in Cardiac Metabolism; PGC-1α sparks the fire of neuroprotection against neurodegenerative disorders; SOX11: friend or foe in tumor prevention and carcinogenesis?; Pterostilbene exerts anticancer activity on non-small-cell lung cancer via activating endoplasmic reticulum stress; AMP-activated protein kinase sparks the fire of cardioprotection against myocardial ischemia and cardiac ageing; STAT3: The art of multi-tasking of metabolic and immune functions in obesity; Novel role of COX6c in the regulation of oxidative phosphorylation and diseases; Blossoming 20: The Energetic Regulator's Birthday Unveils its Versatility in Cardiac Diseases. Representative work: Atherosclerosis is the main pathological basis of ischemic cardiovascular and cerebrovascular diseases and has attracted more attention in recent years. Multiple studies have demonstrated that the signal transducer and activator of transcription 3 (STAT3) plays essential roles in the process of atherosclerosis. Moreover, aberrant STAT3 activation has been shown to contribute to the occurrence and development of atherosclerosis. Therefore, the study of STAT3 inhibitors has gradually become a focal research topic. In this review, we describe the crucial roles of STAT3 in endothelial cell dysfunction, macrophage polarization, inflammation, and immunity during atherosclerosis. STAT3 in mitochond The peroxisome proliferator-activated receptor γ (PPARγ) coactivator-1s (PGC-1s) can induce the expression of several downstream genes that play pivotal roles in the regulation of mitochondrial biogenesis and metabolism in the heart. Moreover, PGC-1 signaling pathways have also been reported to play a critical role in cardioprotection. Given the significance of PGC-1 coactivators, we summarize the current literature on the molecular mechanisms and roles of PGC-1s in cardiac metabolism. Thus, in this review, we first introduce the basic knowledge regarding PGC-1 signaling pathways. We then discuss their roles in heart metabolism. Moreover, we describe several significant treatments that targe

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