Area of research
Molecular Biology · Cell Biology
Research interest
Research interests include Protein Kinase Regulation and GTPase Signaling, Cellular transport and secretion, PI3K/AKT/mTOR signaling in cancer, and Receptor Mechanisms and Signaling.
Penetrant PKCβ mutation in ATLL displays a mixed gain-of-function.
Drug-resistant EGFR mutations promote lung cancer by stabilizing interfaces in ligand-free kinase-active EGFR oligomers
Functional Engagement of the PD-1/PD-L1 Complex But Not PD-L1 Expression Is Highly Predictive of Patient Response to Immunotherapy in Non–Small-Cell Lung Cancer
Functional Engagement of the PD-1/PD-L1 Complex But Not PD-L1 Expression Is Highly Predictive of Patient Response to Immunotherapy in Non-Small-Cell Lung Cancer.
Cell cycle responses to Topoisomerase II inhibition: Molecular mechanisms and clinical implications.
Chemical Genetic Identification of PKC Epsilon Substrates in Mouse Brain
The T766M-EGFR lung cancer mutation promotes tumor growth by exploiting newfound mechanisms assembling ligand-free EGFR oligomer structures
Control of atypical PKCι membrane dissociation by tyrosine phosphorylation within a PB1-C1 interdomain interface
Into the fold: advances in understanding aPKC membrane dynamics.
The <i>Candida albicans</i> toxin candidalysin mediates distinct epithelial inflammatory responses through p38 and EGFR-ERK pathways.
Editorial: Signaling by Small GTPases in Metastatic Disease.
Determinants of anti-PD-1 response and resistance in clear cell renal cell carcinoma.
Immunogenomics of Colorectal Cancer Response to Checkpoint Blockade: Analysis of the KEYNOTE 177 Trial and Validation Cohorts
Immunogenomics of Colorectal Cancer Response to Checkpoint Blockade: Analysis of the KEYNOTE 177 Trial and Validation Cohorts.
Equivocal, explicit and emergent actions of PKC isoforms in cancer.
A genetically-encoded crosslinker screen identifies SERBP1 as a PKCε substrate influencing translation and cell division.
<i>ImmunoCluster</i> provides a computational framework for the nonspecialist to profile high-dimensional cytometry data.
Co-ordinated control of the Aurora B abscission checkpoint by PKCε complex assembly, midbody recruitment and retention.
Quantification of biomarker functionality predicts patient outcomes.
Representative Sequencing: Unbiased Sampling of Solid Tumor Tissue
Equivocal, explicit and emergent actions of PKC isoforms in cancer
High PD-1/PD-L1 Checkpoint Interaction Infers Tumor Selection and Therapeutic Sensitivity to Anti-PD-1/PD-L1 Treatment
The Aurora B specificity switch is required to protect from non-disjunction at the metaphase/anaphase transition.
A small molecule inhibitor of HER3: a proof-of-concept study.
A cancer-associated, genome protective programme engaging PKCε.
Immunogenomic profile of colorectal cancer response to immune checkpoint blockade
Immune-checkpoint engagement as predictive biomarkers in clear cell renal cell carcinoma and melanoma
A genome-wide RNAi screen identifies the SMC5/6 complex as a non-redundant regulator of a Topo2a-dependent G2 arrest.
The Rho family GEF FARP2 is activated by aPKCι to control tight junction formation and polarity.