Area of research
Cancer Research · Molecular Biology
Research interest
Research interests include Cancer Genomics and Diagnostics, Epigenetics and DNA Methylation, Acute Myeloid Leukemia Research, and PARP inhibition in cancer therapy.
Germline MBD4 deficiency causes a multi-tumor predisposition syndrome
Molecular patterns of response and treatment failure after frontline venetoclax combinations in older patients with AML
A missense mutation in the MLKL brace region promotes lethal neonatal inflammation and hematopoietic dysfunction
MBD4 guards against methylation damage and germ line deficiency predisposes to clonal hematopoiesis and early-onset AML
The BRCA1ness signature is associated significantly with response to PARP inhibitor treatment versus control in the I-SPY 2 randomized neoadjuvant setting
PIK3CA mutations are associated with reduced pathological complete response rates in primary HER2-positive breast cancer: pooled analysis of 967 patients from five prospective trials investigating lapatinib and trastuzumab
Abstract A30: RATHER: High-resolution molecular profiling of invasive lobular breast cancers
Development of a BRCA1-Like Signature in Triple Negative Breast Cancers Within the Rather (Rational Therapy for Breast Cancer) Consortium
The Pseudokinase MLKL Mediates Necroptosis via a Molecular Switch Mechanism
Abstract P6-04-02: Defining clinically relevant molecular subtypes in lobular breast cancer within the RATHER consortium
Abstract 4022: BRCA1-like signature in triple negative breast cancers within the RATHER (Rational Therapy for Breast Cancer) Consortium.
A robust genomic signature for the detection of colorectal cancer patients with microsatellite instability phenotype and high mutation frequency