Area of research
Molecular Biology · Cancer Research
Research interest
Research interests include RNA modifications and cancer, RNA Research and Splicing, RNA and protein synthesis mechanisms, and Genomics and Chromatin Dynamics.
Investigation of TRMT61B methyltransferase activity on mRNA and its effects on translation.
Histone H4 acetyl-methyllysine marks accessible chromatin that resists compaction
Transcription elongation factor ELOF1 is required for efficient somatic hypermutation and class switch recombination
RBM15-MKL1 fusion protein promotes leukemia via m6A methylation and Wnt pathway activation.
Uncovering the isoform-resolution kinetic landscape of nonsense-mediated mRNA decay with EZbakR
RNADecayCafe, a uniformly processed atlas of RNA half-life estimates across multiple human cell lines
MYOD represses gene expression from non-E-box motifs.
RBM15-MKL1 fusion protein promotes leukemia via m6A methylation and WNT pathway activation
Investigation of TRMT61B methyltransferase activity on mRNA and its effects on translation
Transcription elongation defects link oncogenic SF3B1 mutations to targetable alterations in chromatin landscape
Phosphorylation of the nuclear poly(A) binding protein (PABPN1) during mitosis protects mRNA from hyperadenylation and maintains transcriptome dynamics.
Disulfide Tethering to Map Small Molecule Binding Sites Transcriptome-wide.
Expanding and improving analyses of nucleotide recoding RNA-seq experiments with the EZbakR suite
Transcription elongation factor ELOF1 is required for efficient somatic hypermutation and class switch recombination
Rapid folding of nascent RNA regulates eukaryotic RNA biogenesis
E-box independent chromatin recruitment turns MYOD into a transcriptional repressor
ALKBH5 modulates hematopoietic stem and progenitor cell energy metabolism through m6A modification-mediated RNA stability control
bakR: uncovering differential RNA synthesis and degradation kinetics transcriptome-wide with Bayesian hierarchical modeling.
Acetyl-methyllysine marks chromatin at active transcription start sites.
Catalytic and non-catalytic mechanisms of histone H4 lysine 20 methyltransferase SUV420H1
Systematic detection of tertiary structural modules in large RNAs and RNP interfaces by Tb-seq
Systematic detection of tertiary structural modules in large RNAs and RNP interfaces by Tb-seq.
Catalytic and non-catalytic mechanisms of histone H4 lysine 20 methyltransferase SUV420H1
Transcription elongation defects link oncogenic splicing factor mutations to targetable alterations in chromatin landscape
Improving the study of RNA dynamics through advances in RNA-seq with metabolic labeling and nucleotide-recoding chemistry
Precision analysis of mutant U2AF1 activity reveals deployment of stress granules in myeloid malignancies
Targeted Degradation of mRNA Decapping Enzyme DcpS by a VHL-Recruiting PROTAC.
Internally controlled RNA sequencing comparisons using nucleoside recoding chemistry.
Differential kinetic analysis using nucleotide recoding RNA-seq and bakR
Genome-wide CRISPR Screens Reveal Host Factors Critical for SARS-CoV-2 Infection.