Area of research
Neurology · Genetics
Research interest
Research interests include Amyotrophic Lateral Sclerosis Research, Parkinson's Disease Mechanisms and Treatments, Neurogenetic and Muscular Disorders Research, and Autophagy in Disease and Therapy.
Myristoylation of TMEM106B by NMT1/2 regulates TMEM106B trafficking and turnover
Loss of TMEM106B exacerbates Tau pathology and neurodegeneration in PS19 mice
C9ORF72 suppresses JAK-STAT mediated inflammation
CRISPR-Cas and catalytic hairpin assembly technology for target-initiated amplification detection of pancreatic cancer specific tsRNAs
Progranulin-derived granulin E and lysosome membrane protein CD68 interact to reciprocally regulate their protein homeostasis
Physiological and pathological functions of TMEM106B: a gene associated with brain aging and multiple brain disorders
Regulation of lysosomal trafficking of progranulin by sortilin and prosaposin
Loss of TMEM106B and PGRN leads to severe lysosomal abnormalities and neurodegeneration in mice
Cellular and physiological functions of C9ORF72 and implications for ALS/FTD
A role of the frontotemporal lobar degeneration risk factor TMEM106B in myelination
Dextran-coated iron oxide nanoparticle-induced nanotoxicity in neuron cultures
Progranulin deficiency leads to reduced glucocerebrosidase activity
The lysosomal function of progranulin, a guardian against neurodegeneration
Impaired prosaposin lysosomal trafficking in frontotemporal lobar degeneration due to progranulin mutations
Regulation of cathepsin D activity by the FTLD protein progranulin
Lysosomal processing of progranulin
The ALS/FTLD associated protein C9orf72 associates with SMCR8 and WDR41 to regulate the autophagy-lysosome pathway
Prosaposin facilitates sortilin-independent lysosomal trafficking of progranulin
Expression of TMEM106B, the frontotemporal lobar degeneration-associated protein, in normal and diseased human brain
The frontotemporal lobar degeneration risk factor, TMEM106B, regulates lysosomal morphology and function
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