Area of research
Immunology · Molecular Biology
Research interest
Research interests include Inflammasome and immune disorders, interferon and immune responses, Immune Response and Inflammation, and IL-33, ST2, and ILC Pathways.
Genetic variants in UNC93B1 predispose to childhood-onset systemic lupus erythematosus
ZAKα-driven ribotoxic stress response activates the human NLRP1 inflammasome
DPP9 deficiency: An inflammasomopathy that can be rescued by lowering NLRP1/IL-1 signaling
Whole-genome sequencing reveals that variants in the Interleukin 18 Receptor Accessory Protein 3′UTR protect against ALS
TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activate cGAS/STING in ALS
A missense mutation in the MLKL brace region promotes lethal neonatal inflammation and hematopoietic dysfunction
Excessive deubiquitination of NLRP3-R779C variant contributes to very-early-onset inflammatory bowel disease development
Mutations that prevent caspase cleavage of RIPK1 cause autoinflammatory disease
RIPLET, and not TRIM25, is required for endogenous RIG‐I‐dependent antiviral responses
TRAIL-Expressing Monocyte/Macrophages Are Critical for Reducing Inflammation and Atherosclerosis
Evidence that TLR4 Is Not a Receptor for Saturated Fatty Acids but Mediates Lipid-Induced Inflammation by Reprogramming Macrophage Metabolism
Human DPP9 represses NLRP1 inflammasome and protects against autoinflammatory diseases via both peptidase activity and FIIND domain binding
NLRP1 restricts butyrate producing commensals to exacerbate inflammatory bowel disease
NLRP3 inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in mice
Homeostasis-altering molecular processes as mechanisms of inflammasome activation
EspL is a bacterial cysteine protease effector that cleaves RHIM proteins to block necroptosis and inflammation
Germline NLRP1 Mutations Cause Skin Inflammatory and Cancer Susceptibility Syndromes via Inflammasome Activation
Familial autoinflammation with neutrophilic dermatosis reveals a regulatory mechanism of pyrin activation
A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases
RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL
A Toxoplasma gondii Gluconeogenic Enzyme Contributes to Robust Central Carbon Metabolism and Is Essential for Replication and Virulence
RIPK1 Regulates RIPK3-MLKL-Driven Systemic Inflammation and Emergency Hematopoiesis
Adipose Tissue Macrophages Promote Myelopoiesis and Monocytosis in Obesity
Dual Role for Inflammasome Sensors NLRP1 and NLRP3 in Murine Resistance to Toxoplasma gondii
Succinate is an inflammatory signal that induces IL-1β through HIF-1α