Area of research
Immunology · Surgery
Research interest
Research interests include IL-33, ST2, and ILC Pathways, Immune Cell Function and Interaction, Eosinophilic Esophagitis, and Gut microbiota and health.
IL-33-activated ILC2s induce tertiary lymphoid structures in pancreatic cancer
Host metabolism balances microbial regulation of bile acid signalling
Microbiota-derived bile acids antagonize the host androgen receptor and drive anti-tumor immunity
The sensory neuroimmune frontier
Tuft cell IL-17RB restrains IL-25 bioavailability and reveals context-dependent ILC2 hypoproliferation
Microbiota-mediated mechanisms of mucosal immunity across the lifespan
Group 2 innate lymphoid cells regulate nociceptive and gait functions of the peripheral nervous system
Microbiota metabolism of intestinal amino acids impacts host nutrient homeostasis and physiology
Nutritional regulation of microbiota-derived metabolites: Implications for immunity and inflammation
Therapeutic application of human type 2 innate lymphoid cells via induction of granzyme B-mediated tumor cell death
Dietary fiber is a critical determinant of pathologic ILC2 responses and intestinal inflammation
CTLA-4-expressing ILC3s restrain interleukin-23-mediated inflammation
Spatially restricted immune and microbiota-driven adaptation of the gut
Fungal symbiont transmitted by free-living mice promotes type 2 immunity
Group 2 innate lymphoid cells are a non-redundant source of interleukin-5 required for development and function of murine B1 cells
Sensory neurons promote immune homeostasis in the lung
Droplet-based forward genetic screening of astrocyte–microglia cross-talk
Neuroimmune interplay during type 2 inflammation: Symptoms, mechanisms, and therapeutic targets in atopic diseases
Cooperation of ILC2s and TH2 cells in the expulsion of intestinal helminth parasites
ILC2 require cell-intrinsic ST2 signals to promote type 2 immune responses
ILC3s select microbiota-specific regulatory T cells to establish tolerance in the gut
Inulin fibre promotes microbiota-derived bile acids and type 2 inflammation
Genetic manipulation of gut microbes enables single-gene interrogation in a complex microbiome
Gut-innervating nociceptors regulate the intestinal microbiota to promote tissue protection
Non-redundant functions of group 2 innate lymphoid cells
Neuropeptide regulation of non-redundant ILC2 responses at barrier surfaces
ZBTB46 defines and regulates ILC3s that protect the intestine
Joint single-cell measurements of nuclear proteins and RNA in vivo
The ChAT-acetylcholine pathway promotes group 2 innate lymphoid cell responses and anti-helminth immunity
Neuro-immune Interactions in the Tissues