Area of research
Molecular Biology · Biomedical Engineering
Research interest
Research interests include Advanced biosensing and bioanalysis techniques, Biosensors and Analytical Detection, RNA Interference and Gene Delivery, and DNA and Nucleic Acid Chemistry.
In Vivo Spatiotemporal Protection and Recognition of Circulating Tumor DNA for Early Cancer Diagnosis and Monitoring.
Target-Activated and Movable Toehold-Assisted Proximal Catalytic Hairpin Assembly Amplification for Low-Leakage and Ultrasensitive Fluorescent Aptamer Sensing of Glycated Hemoglobin A1c.
Ultrasensitive electrochemical aptasensor for soluble CD80 biomarker based on cascaded DNA assembly and catalytic redox-recycling amplifications
Target-induced recycling and self-folding hairpin primer-mediated LAMP activation of CRISPR/Cas12a for highly sensitive aptamer-based therapeutic antibody assay.
<i>In situ</i> partial vulcanization synthesis of a conductive and highly catalytic bimetal organic framework for sensitive electrochemical cancer-specific neoantigen detection.
Highly Catalytic FeS<sub>2</sub>@CoS<sub>2</sub> Core/Shell Nanocubes for Ultrasensitive Electrochemical Assay of Microphthalmia-Associated Transcription Factor via Nucleic Acid Signal Amplification Cascades.
Highly Sensitive and Specific Detection of Autophagy Signaling Pathway in Live Cancer Cells for Chemoresistance Assessment via ZnO-DNA Nanosphere Probes.
DNA-Assembled Size-Permeable Microcapsule Bioreactor Enables Direct and Rapid Sensing of Trace Circulating MicroRNA Biomarkers in Undiluted Cancer Patient Serum.
Simultaneous and Sensitive Sensing of Intracellular MicroRNA and mRNA for the Detection of the PI3K/AKT Signaling Pathway in Live Cells.
Target-initiated triplex signal amplification cascades for non-label and sensitive fluorescence sensing of microRNA.
Multicolor-Encoded DNA Framework Enables Specific and Amplified In Situ Detection of the Mitochondrial Apoptotic Signaling Pathway.
A metal ion-coordinated DNA probe for sensitive fluorescence detection of metallothionein <i>via</i> a dual nucleic acid amplification strategy.
An aptamer triple helix molecular switch for sensitive electrochemical assay of lipocalin 1 biomarker <i>via</i> dual signal amplifications.
Self-constrained DNAzyme for aptamer-based and sensitive label-free fluorescent assay of sarafloxacin <i>via</i> signal amplification cascades.
Associations of Dietary Inflammatory Index With Prediabetes and Insulin Resistance
Biomimetic nanoparticles for effective mild temperature photothermal therapy and multimodal imaging
Robust DNA Cross-Linked Polymeric Lighting-Up Nanogel Facilitates Sensitive Live Cell MicroRNA Imaging.
Size-Discriminative DNA Nanocage Framework Enables Sensitive and High-Fidelity Imaging of Mature MicroRNA in Living Cells.
A bivalent aptamer and terminus-free siRNA junction nanostructure for targeted gene silencing in cancer cells.
A stimulus-responsive hexahedron DNA framework facilitates targeted and direct delivery of native anticancer proteins into cancer cells.
3D DNA Scaffold-Assisted Dual Intramolecular Amplifications for Multiplexed and Sensitive MicroRNA Imaging in Living Cells.
High-Fidelity and Simultaneous Sensing of Endogenous Mutant and Wild p53 Proteins for Precise Cancer Diagnosis and Drug Screening.
Target-induced activation of polymerase activity for recycling signal amplification cascades for sensitive aptamer-based detection of biomarkers
Efficient and Exponential Rolling Circle Amplification Molecular Network Leads to Ultrasensitive and Label-Free Detection of MicroRNA.
<i>In Situ</i>-Generated Multivalent Aptamer Network for Efficient Capture and Sensitive Electrochemical Detection of Circulating Tumor Cells in Whole Blood.
An efficient, label-free and sensitive electrochemical microRNA sensor based on target-initiated catalytic hairpin assembly of trivalent DNAzyme junctions
Lighting-up RNA aptamer transcription synchronization amplification for ultrasensitive and label-free imaging of microRNA in single cells
Target-induced autonomous synthesis of G-quadruplex sequences for label-free and amplified fluorescent aptasensing of mucin 1
Targeted Delivery of DNA Framework-Encapsulated Native Therapeutic Protein into Cancer Cells.
Polymerization nicking-triggered LAMP cascades enable exceptional signal amplification for aptamer-based label-free detection of trace proteins in human serum