Area of research
Materials Chemistry · Molecular Biology
Research interest
Research interests include Enzyme Structure and Function, Protein Structure and Dynamics, Amino Acid Enzymes and Metabolism, and Genetics, Bioinformatics, and Biomedical Research.
The <i>SORL1</i> p.Y1816C variant causes impaired endosomal dimerization and autosomal dominant Alzheimer's disease.
Evaluating protein cross-linking as a therapeutic strategy to stabilize SOD1 variants in a mouse model of familial ALS
RIOK2 transcriptionally regulates TRiC and dyskerin complexes to prevent telomere shortening.
Dimerization of the Alzheimer's disease pathogenic receptor SORLA regulates its association with retromer.
On the causal role of retromer-dependent endosomal recycling in Alzheimer's disease.
Chemically stable fluorescent proteins for advanced microscopy
Chemically stable fluorescent proteins for advanced microscopy.
The neuronal retromer can regulate both neuronal and microglial phenotypes of Alzheimer's disease
The neuronal retromer can regulate both neuronal and microglial phenotypes of Alzheimer's disease
Brain-wide analysis of the supraspinal connectome reveals anatomical correlates to functional recovery after spinal injury.
Brain-wide analysis of the supraspinal connectome reveals anatomical correlates to functional recovery after spinal injury
Identification of RIOK2 as a master regulator of human blood cell development.
Structural analysis of human CEACAM1 oligomerization.
Author response: Brain-wide analysis of the supraspinal connectome reveals anatomical correlates to functional recovery after spinal injury
A new alpha-synuclein missense variant (Thr72Met) in two Turkish families with Parkinson's disease
Seeing gene expression in cells: the future of structural biology.
Personalized iPSC-Derived Dopamine Progenitor Cells for Parkinson’s Disease
mGreenLantern: a bright monomeric fluorescent protein with rapid expression and cell filling properties for neuronal imaging
mGreenLantern: a bright monomeric fluorescent protein with rapid expression and cell filling properties for neuronal imaging.
25-Hydroxycholesterol amplifies microglial IL-1β production in an apoE isoform-dependent manner
PGE1 and PGA1 bind to Nurr1 and activate its transcriptional function.
Endosomal recycling reconciles the Alzheimer's disease paradox.
Acquired resistance to IDH inhibition through trans or cis dimer-interface mutations
AAVrh.10-Mediated APOE2 Central Nervous System Gene Therapy for APOE4-Associated Alzheimer's Disease
Stabilizing the Retromer Complex in a Human Stem Cell Model of Alzheimer’s Disease Reduces TAU Phosphorylation Independently of Amyloid Precursor Protein
Parkinson’s Disease and Melanoma: Co-Occurrence and Mechanisms
Cholera toxin inhibits SNX27-retromer-mediated delivery of cargo proteins to the plasma membrane
Endosomal Traffic Jams Represent a Pathogenic Hub and Therapeutic Target in Alzheimer’s Disease
Caspase-1 causes truncation and aggregation of the Parkinson’s disease-associated protein α-synuclein
Reducing C-terminal truncation mitigates synucleinopathy and neurodegeneration in a transgenic model of multiple system atrophy
How Organisms Adapt to New Enzymes and Pathways
U.S.-Japan Cooperative Science: The Interrelationship of Protein Flexibility, Activity and Thermal Stability
Data Collection Instrumentation for Protein Crystallography
Purchase of Equipment For X-Ray Studies
Protein Crystallography at Sub-Zero Temperatures
Protein Crystallography at Sub-Zero Temperatures
Protein Crystallography at Sub-Zero Temperatures