Area of research
Neurology · Organic Chemistry
Research interest
Research interests include Neurological Disease Mechanisms and Treatments, Nitric Oxide and Endothelin Effects, Synthesis and biological activity, and Traditional Chinese Medicine Analysis.
S-Nitrosation-Based Target Discovery and Drug Development: Toward a Nitric Oxide Drug 2.0 Paradigm.
Ischemic stroke and intervention strategies based on the timeline of stroke progression: Review and prospects
A novel anti-ischemic stroke candidate drug AAPB with dual effects of neuroprotection and cerebral blood flow improvement
Cellular Metabolomics Reveals Differences in the Scope of Liver Protection Between Ammonium-Based Glycyrrhizinate and Magnesium Isoglycyrrhizinate
Design, Synthesis, and Anti-ischemic Stroke Activity Evaluation of Novel GSNOR Inhibitors.
Warhead Strategy for Targeted Protein S-Nitrosation.
Anti-CD24 antibody-nitric oxide donor conjugates bearing a self-bioorthogonal cleavable linker
Drugs/agents for the treatment of ischemic stroke: Advances and perspectives.
Development of Integrated Bioorthogonal Self-Catalyzed NO Donor/Platinum(IV) Prodrugs for Synergistical Intervention against Triple-Negative Breast Cancer.
Construction of New MRI Contrast Agents for Spatiotemporal Visualization of Nitric Oxide in Ischemia/Reperfusion Organs.
Development of Nitric Oxide-Donating Netarsudil Derivatives as a Synergistic Therapy for Glaucoma with Reduced Ocular Irritation.
In Situ Embedding Hydrogen‐Bonded Organic Frameworks Nanocrystals in Electrospinning Nanofibers for Ultrastable Broad‐Spectrum Antibacterial Activity
Advances in nitric oxide regulators for the treatment of ischemic stroke
Glutamylation of an HIV-1 protein inhibits the immune response by hijacking STING
1,3-Substituted β-Carboline Derivatives as Potent Chemotherapy for the Treatment of Cystic Echinococcosis
1,3-Substituted β-Carboline Derivatives as Potent Chemotherapy for the Treatment of Cystic Echinococcosis.
Novel Nitric Oxide Donor-Azole Conjugation Strategy for Efficient Treatment of <i>Cryptococcus neoformans</i> Infections.
Protein <i>S</i>-Nitrosation: Biochemistry, Identification, Molecular Mechanisms, and Therapeutic Applications.
A Novel Hybrid of Telmisartan and Borneol Ameliorates Neuroinflammation and White Matter Injury in Ischemic Stroke Through ATF3/CH25H Axis
Identification of Nitric Oxide-Donating Ripasudil Derivatives with Intraocular Pressure Lowering and Retinal Ganglion Cell Protection Activities.
One Stone Two Birds: Redox-Sensitive Colocalized Delivery of Cisplatin and Nitric Oxide through Cascade Reactions.
HIV-1 Vif suppresses antiviral immunity by targeting STING
Design, Synthesis, and Biological Evaluation of Organic Nitrite (NO<sub>2</sub><sup>-</sup>) Donors as Potential Anticerebral Ischemia Agents.
Candidate gene prioritization for chronic obstructive pulmonary disease using expression information in protein–protein interaction networks
β-arrestin 2 as an activator of cGAS-STING signaling and target of viral immune evasion
Identification of New Nitric Oxide-Donating Peptides with Dual Biofilm Eradication and Antibacterial Activities for Intervention of Device-Related Infections.
From Seeds of <i>Apium graveolens</i> Linn. to a Cerebral Ischemia Medicine: The Long Journey of 3-<i>n</i>-Butylphthalide.
General Strategy for Integrated Bioorthogonal Prodrugs: Pt(II)-Triggered Depropargylation Enables Controllable Drug Activation <i>In Vivo</i>.
SHP‐1 suppresses the antiviral innate immune response by targeting TRAF3
Tetrazine-mediated bioorthogonal removal of 3-isocyanopropyl groups enables the controlled release of nitric oxide <i>in vivo</i>