Area of research
Parasitology · Public Health, Environmental and Occupational Health
Research interest
Pathogenesis of Pulmonary Bacterial Pathogen Infection Ph.D.: University of Oklahoma, Norman, Oklahoma Postdoctoral: National Institutes of Health, Rocky Mountain Laboratories, Laboratory of Intracellular Parasites, Hamilton, Montana Phone: 501-686-8050 Fax: 501-686-5359 Email: DVoth@uams.edu Lab Webpage Research Description The Voth laboratory uses novel human-derived models of infection to study bacterial pathogens that establish pulmonary infections in humans. The first pathogen of interest, Coxiella burnetii , causes human Q fever, which typically presents as an acute debilitating flu-like disease complicated by pneumonia. However, chronic infection can occur and normally manifests as life-threatening endocarditis. In humans, Coxiella replicates to high numbers in alveolar macrophages
Dragan, A.L., Voth, D.E. (2020) Coxiella burnetii: international pathogen of mystery. Microbes Infect. 22(3):100-110.
— 2020cited by 0position: selected
Brann, K.R., Fullerton, M.S., and Voth, D.E. (2020). Coxiella burnetii Requires Host Eukaryotic Initiation Factor 2α Activity for Efficient Intracellular Replication. Infect Immun. 88(7):e00096-20.
— 2020cited by 0position: selected
Brann, K.R., Fullerton, M.S., Onyilagha, F.I., Prince, A.A., Kurten, R.C., Rom, J.S., Blevins, J.S., Smeltzer, M.S., Voth, D.E. 2019. Infection of Primary Human Alveolar Macrophages Alters Staphylococcus aureus Toxin Production and Activity. Infect Immun . 20;87(7). pii: e00167-19.
— 2019cited by 0position: selected
Winchell, C.G., Dragan, A.L., Doiron, K.R., Onyilagha, F.I., Kurten, R.C., and D.E. Voth (2018) Coxiella burnetii Subverts p62/Sequestosome 1 and Activates Nrf2 Signaling in Human Macrophages. Infection and Immunity . 86: e00608-17 .
— 2018cited by 0position: selected
Colonne, P.M., Winchell, C.G., Graham, J.G., Onyilagha, F.I., MacDonald, L.J., Doeppler, H.R., Storz, P., Kurten, R.C., Beare, P.A., Heinzen, R.A., and D.E. Voth (2016) Vasodilator-Stimulated Phosphoprotein Activity is Required for Coxiella burnetii Growth in Human Macrophages. PLoS Pathogens. 12:
— 2016cited by 0position: selected
Graham, J.G., Winchell, C.G., Kurten, R.C., and D.E. Voth (2016) Development of an ex vivo Tissue Platform to Study the Human Lung Response to Coxiella burnetii . Infection and Immunity. 84: 1438-1445 .
— 2016cited by 0position: selected
Winchell, C.G., Graham, J.G., Kurten, R.C., and D.E. Voth (2014) Coxiella burnetii Type IV Secretion-Dependent Recruitment of Macrophage Autophagosomes . Infection and Immunity . 82: 2229-2238.
— 2014cited by 0position: selected