Area of research
Neurology · Immunology
Research interest
Research interests include Neuroinflammation and Neurodegeneration Mechanisms, Immune cells in cancer, Alzheimer's disease research and treatments, and Immune Response and Inflammation.
A transcriptomic microglia taxonomy across mouse and human pathologies
Immune checkpoint TIM-3 regulates microglia and Alzheimer’s disease
TDP-43 loss induces cryptic polyadenylation in ALS/FTD
Radial glia integrin avb8 regulates cell autonomous microglial TGFβ1 signaling that is necessary for microglial identity
Neuroinflammation in Alzheimer disease
Sodium oligomannate alters gut microbiota, reduces cerebral amyloidosis and reactive microglia in a sex-specific manner
Author Correction: TDP-43 loss and ALS-risk SNPs drive mis-splicing and depletion of UNC13A
APOE4 impairs the microglial response in Alzheimer’s disease by inducing TGFβ-mediated checkpoints
Identification of a protective microglial state mediated by miR-155 and interferon-γ signaling in a mouse model of Alzheimer’s disease
Sex-specific microglia state in the Neuroligin-4 knock-out mouse model of autism spectrum disorder
Microglia states and nomenclature: A field at its crossroads
TDP-43 loss and ALS-risk SNPs drive mis-splicing and depletion of UNC13A
The cytokines interleukin-6 and interferon-α induce distinct microglia phenotypes
Cell environment shapes TDP-43 function with implications in neuronal and muscle disease
Regulating microglial miR-155 transcriptional phenotype alleviates Alzheimer’s-induced retinal vasculopathy by limiting Clec7a/Galectin-3+ neurodegenerative microglia
Selective removal of astrocytic APOE4 strongly protects against tau-mediated neurodegeneration and decreases synaptic phagocytosis by microglia
An integrated multi-omic analysis of iPSC-derived motor neurons from C9ORF72 ALS patients
Type I interferon response drives neuroinflammation and synapse loss in Alzheimer disease
Microglia, Lifestyle Stress, and Neurodegeneration
Inhibition of colony stimulating factor 1 receptor corrects maternal inflammation-induced microglial and synaptic dysfunction and behavioral abnormalities
Postmortem Cortex Samples Identify Distinct Molecular Subtypes of ALS: Retrotransposon Activation, Oxidative Stress, and Activated Glia
Sex-specific effects of microbiome perturbations on cerebral Aβ amyloidosis and microglia phenotypes
Microglial signatures and their role in health and disease
Competitive repopulation of an empty microglial niche yields functionally distinct subsets of microglia-like cells
Fatal demyelinating disease is induced by monocyte-derived macrophages in the absence of TGF-β signaling
The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases
Microglia Function in the Central Nervous System During Health and Neurodegeneration
ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy
Loss of ‘homeostatic’ microglia and patterns of their activation in active multiple sclerosis
TREM2 deficiency impairs chemotaxis and microglial responses to neuronal injury