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Mathias Jucker

Yale University · DE
Area of research
Physiology · Psychiatry and Mental health
Research interest
Research interests include Alzheimer's disease research and treatments, Dementia and Cognitive Impairment Research, Prion Diseases and Protein Misfolding, and Neuroinflammation and Neurodegeneration Mechanisms.
h-index
93
citations
38,416
works
394
NIH funding
primary concept
Biology
email

Recent publications

Safety and efficacy of long-term gantenerumab treatment in dominantly inherited Alzheimer's disease: an open-label extension of the phase 2/3 multicentre, randomised, double-blind, placebo-controlled platform DIAN-TU trial
The Lancet Neurology 2025cited by 34position: middledoi
Longitudinal analysis of a dominantly inherited Alzheimer disease mutation carrier protected from dementia
Nature Medicine 2025cited by 21position: middledoi
Integrative multiomics reveals common endotypes across PSEN1, PSEN2, and APP mutations in familial Alzheimer’s disease
Alzheimer s Research & Therapy 2025cited by 13position: middledoi
The landscape of autosomal-dominant Alzheimer’s disease: global distribution and age of onset
Brain 2025cited by 12position: middledoi
The relationship of soluble tau species with Alzheimer's disease amyloid plaque removal and tau pathology
Alzheimer s & Dementia 2025cited by 3position: middledoi
Sample size estimates for biomarker-based outcome measures in clinical trials in autosomal dominant Alzheimer's disease
The Journal of Prevention of Alzheimer s Disease 2025cited by 2position: middledoi
Downstream Biomarker Effects of Gantenerumab or Solanezumab in Dominantly Inherited Alzheimer Disease
JAMA Neurology 2024cited by 27position: middledoi
Comparative neurofilament light chain trajectories in CSF and plasma in autosomal dominant Alzheimer’s disease
Nature Communications 2024cited by 22position: middledoi
The prion principle and Alzheimer’s disease
Science 2024cited by 20position: lastdoi
Sample size estimates for biomarker-based outcome measures in clinical trials in autosomal dominant Alzheimer’s disease
medRxiv 2024cited by 0position: middledoi
Alzheimer's disease: From immunotherapy to immunoprevention
Cell 2023cited by 322position: firstdoi
Cerebrospinal fluid proteomics define the natural history of autosomal dominant Alzheimer’s disease
Nature Medicine 2023cited by 168position: middledoi
Etiology of White Matter Hyperintensities in Autosomal Dominant and Sporadic Alzheimer Disease
JAMA Neurology 2023cited by 84position: middledoi
Medin co-aggregates with vascular amyloid-β in Alzheimer’s disease
Nature 2022cited by 105position: middledoi
Plasma glial fibrillary acidic protein in autosomal dominant Alzheimer's disease: Associations with Aβ‐PET, neurodegeneration, and cognition
Alzheimer s & Dementia 2022cited by 83position: middledoi
Autosomal dominant and sporadic late onset Alzheimer's disease share a common<i>in vivo</i>pathophysiology
Brain 2022cited by 58position: middledoi
Experimental evidence for temporal uncoupling of brain Aβ deposition and neurodegenerative sequelae
Nature Communications 2022cited by 27position: lastdoi
Signatures of glial activity can be detected in the CSF proteome
Proceedings of the National Academy of Sciences 2022cited by 23position: middledoi
Accelerated functional brain aging in pre-clinical familial Alzheimer’s disease
Nature Communications 2021cited by 100position: middledoi
A soluble phosphorylated tau signature links tau, amyloid and the evolution of stages of dominantly inherited Alzheimer’s disease
Nature Medicine 2020cited by 655position: middledoi
Acute targeting of pre-amyloid seeds in transgenic mice reduces Alzheimer-like pathology later in life
Nature Neuroscience 2020cited by 86position: lastdoi
Potential human transmission of amyloid β pathology: surveillance and risks
The Lancet Neurology 2020cited by 69position: middledoi
Systematic review of guidelines for internal validity in the design,conduct and analysis of preclinical biomedical experiments involvinglaboratory animalsSystematic review of guidelines for internal validity inthe design, conduct and analysis of preclinical biomedical experimentsinvolving laboratory animals
BMJ Open Science 2020cited by 64position: middledoi
Serum neurofilament light chain levels are associated with white matter integrity in autosomal dominant Alzheimer's disease
Neurobiology of Disease 2020cited by 60position: middledoi
Serum neurofilament dynamics predicts neurodegeneration and clinical progression in presymptomatic Alzheimer’s disease
Nature Medicine 2019cited by 943position: lastdoi
Cryo-EM structure and polymorphism of Aβ amyloid fibrils purified from Alzheimer’s brain tissue
Nature Communications 2019cited by 595position: middledoi
An atlas of cortical circular RNA expression in Alzheimer disease brains demonstrates clinical and pathological associations
Nature Neuroscience 2019cited by 368position: middledoi
Propagation and spread of pathogenic protein assemblies in neurodegenerative diseases
Nature Neuroscience 2018cited by 452position: firstdoi
Longitudinal cognitive and biomarker changes in dominantly inherited Alzheimer disease
Neurology 2018cited by 317position: middledoi
White matter diffusion alterations precede symptom onset in autosomal dominant Alzheimer’s disease
Brain 2018cited by 181position: middledoi

Grants

No grants ingested yet.

Frequent collaborators

Lary C. Walker · Florey Institute of Neuroscience and Mental Health15 papers (2013–2024)Frank Baumann · University of Tübingen7 papers (2012–2022)Stephan A. Kaeser · German Center for Neurodegenerative Diseases6 papers (2015–2022)Matthias Staufenbiel · University of Tübingen6 papers (2015–2022)Ulrike Obermüller · University of Tübingen6 papers (2015–2022)Jay Rasmussen · University of Tübingen5 papers (2017–2019)Jasmin Mahler · University of Tübingen4 papers (2014–2017)Sarah K. Fritschi · University of Tübingen4 papers (2014–2017)Lan Ye · Medizinische Hochschule Hannover4 papers (2014–2017)Juliane Schelle · University of Tübingen3 papers (2015–2022)Jonas J. Neher · University of Tübingen3 papers (2017–2022)K. Peter R. Nilsson · Linköping University3 papers (2014–2017)Per Hammarström · Science for Life Laboratory3 papers (2014–2017)Lisa M. Häsler · University of Tübingen3 papers (2017–2022)Sangram S. Sisodia · University of Chicago2 papers (2013–2017)Nick C. Fox · Hospital Universitario Ramón y Cajal2 papers (2017–2017)Kaj Blennow · First Affiliated Hospital of Anhui Medical University2 papers (2017–2017)Jasmin K. Hefendehl · Goethe University Frankfurt2 papers (2013–2017)Marius Lambert · University of Tübingen2 papers (2022–2022) · 2 papers (2017–2017)