Area of research
Physiology · Psychiatry and Mental health
Research interest
Research interests include Alzheimer's disease research and treatments, Dementia and Cognitive Impairment Research, Prion Diseases and Protein Misfolding, and Neuroinflammation and Neurodegeneration Mechanisms.
Safety and efficacy of long-term gantenerumab treatment in dominantly inherited Alzheimer's disease: an open-label extension of the phase 2/3 multicentre, randomised, double-blind, placebo-controlled platform DIAN-TU trial
Longitudinal analysis of a dominantly inherited Alzheimer disease mutation carrier protected from dementia
Integrative multiomics reveals common endotypes across PSEN1, PSEN2, and APP mutations in familial Alzheimer’s disease
The landscape of autosomal-dominant Alzheimer’s disease: global distribution and age of onset
The relationship of soluble tau species with Alzheimer's disease amyloid plaque removal and tau pathology
Sample size estimates for biomarker-based outcome measures in clinical trials in autosomal dominant Alzheimer's disease
Downstream Biomarker Effects of Gantenerumab or Solanezumab in Dominantly Inherited Alzheimer Disease
Comparative neurofilament light chain trajectories in CSF and plasma in autosomal dominant Alzheimer’s disease
The prion principle and Alzheimer’s disease
Sample size estimates for biomarker-based outcome measures in clinical trials in autosomal dominant Alzheimer’s disease
Alzheimer's disease: From immunotherapy to immunoprevention
Cerebrospinal fluid proteomics define the natural history of autosomal dominant Alzheimer’s disease
Etiology of White Matter Hyperintensities in Autosomal Dominant and Sporadic Alzheimer Disease
Medin co-aggregates with vascular amyloid-β in Alzheimer’s disease
Plasma glial fibrillary acidic protein in autosomal dominant Alzheimer's disease: Associations with Aβ‐PET, neurodegeneration, and cognition
Autosomal dominant and sporadic late onset Alzheimer's disease share a common<i>in vivo</i>pathophysiology
Experimental evidence for temporal uncoupling of brain Aβ deposition and neurodegenerative sequelae
Signatures of glial activity can be detected in the CSF proteome
Accelerated functional brain aging in pre-clinical familial Alzheimer’s disease
A soluble phosphorylated tau signature links tau, amyloid and the evolution of stages of dominantly inherited Alzheimer’s disease
Acute targeting of pre-amyloid seeds in transgenic mice reduces Alzheimer-like pathology later in life
Potential human transmission of amyloid β pathology: surveillance and risks
Systematic review of guidelines for internal validity in the design,conduct and analysis of preclinical biomedical experiments involvinglaboratory animalsSystematic review of guidelines for internal validity inthe design, conduct and analysis of preclinical biomedical experimentsinvolving laboratory animals
Serum neurofilament light chain levels are associated with white matter integrity in autosomal dominant Alzheimer's disease
Serum neurofilament dynamics predicts neurodegeneration and clinical progression in presymptomatic Alzheimer’s disease
Cryo-EM structure and polymorphism of Aβ amyloid fibrils purified from Alzheimer’s brain tissue
An atlas of cortical circular RNA expression in Alzheimer disease brains demonstrates clinical and pathological associations
Propagation and spread of pathogenic protein assemblies in neurodegenerative diseases
Longitudinal cognitive and biomarker changes in dominantly inherited Alzheimer disease
White matter diffusion alterations precede symptom onset in autosomal dominant Alzheimer’s disease