Area of research
Molecular Biology · Biophysics
Research interest
Research interests include CRISPR and Genetic Engineering, RNA and protein synthesis mechanisms, Advanced biosensing and bioanalysis techniques, and Single-cell and spatial transcriptomics.
Scalable probe-based single-cell transcriptional profiling for virtual cell perturbation mapping and synthetic biology phenotyping
Virtual Cell Challenge: Toward a Turing test for the virtual cell
Megabase-scale human genome rearrangement with programmable bridge recombinases
Site-specific DNA insertion into the human genome with engineered recombinases
A molecular cell atlas of mouse lemur, an emerging model primate
Mouse lemur cell atlas informs primate genes, physiology and disease
An organism-wide atlas of hormonal signaling based on the mouse lemur single-cell transcriptome
DYRK1A promotes viral entry of highly pathogenic human coronaviruses in a kinase-independent manner
Genome-wide bidirectional CRISPR screens identify mucins as host factors modulating SARS-CoV-2 infection
Adversarial domain translation networks for integrating large-scale atlas-level single-cell datasets
CloneSifter: enrichment of rare clones from heterogeneous cell populations
CloneRetriever: retrieval of rare clones from heterogeneous cell populations
DDIS-13. UNDERSTANDING GLIOBLASTOMA SUSCEPTIBILITY TO TOP2-TARGETING DRUGS FOR PERSONALIZED THERAPY
Genome-scale CRISPR-Cas9 knockout and transcriptional activation screening
Genome-scale activation screen identifies a lncRNA locus regulating a gene neighbourhood
C2c2 is a single-component programmable RNA-guided RNA-targeting CRISPR effector
C2c2 is a single-component programmable RNA-guided RNA-targeting CRISPR effector
Discovery and Functional Characterization of Diverse Class 2 CRISPR-Cas Systems
Orthogonal gene knockout and activation with a catalytically active Cas9 nuclease
Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex
Crystal Structure of Cas9 in Complex with Guide RNA and Target DNA
DNA targeting specificity of RNA-guided Cas9 nucleases
Double Nicking by RNA-Guided CRISPR Cas9 for Enhanced Genome Editing Specificity
Optical control of mammalian endogenous transcription and epigenetic states
Double Nicking by RNA-Guided CRISPR Cas9 for Enhanced Genome Editing Specificity