Area of research
Immunology · Oncology
Research interest
Research interests include Cancer Immunotherapy and Biomarkers, Immunotherapy and Immune Responses, Immune Cell Function and Interaction, and T-cell and B-cell Immunology.
The Spectrum of Fibroblast Immune Biology
Fibroblastic FLT3L supports lymph node dendritic cells in the interfollicular niche
Systematic perturbation screens identify regulators of inflammatory macrophage states and a role for TNF mRNA m6A modification
The cancer-immunity cycle: Indication, genotype, and immunotype
CD8+ T cell-intrinsic IL-6 signaling promotes resistance to anti-PD-L1 immunotherapy
Combined PD-L1/TGFβ blockade allows expansion and differentiation of stem cell-like CD8 T cells in immune excluded tumors
In situ tumour arrays reveal early environmental control of cancer immunity
Mesothelial cell-derived antigen-presenting cancer-associated fibroblasts induce expansion of regulatory T cells in pancreatic cancer
LRRC15+ myofibroblasts dictate the stromal setpoint to suppress tumour immunity
Spatial Positioning and Matrix Programs of Cancer-Associated Fibroblasts Promote T-cell Exclusion in Human Lung Tumors
Cross-tissue organization of the fibroblast lineage
Fibroblasts as immune regulators in infection, inflammation and cancer
Fibroblast-macrophage reciprocal interactions in health, fibrosis, and cancer
Single-cell dissection of cellular components and interactions shaping the tumor immune phenotypes in ovarian cancer
The neutrotime transcriptional signature defines a single continuum of neutrophils across biological compartments
Gut CD4+ T cell phenotypes are a continuum molded by microbes, not by TH archetypes
TGFβ biology in cancer progression and immunotherapy
Distinct Mesenchymal Cell Populations Generate the Essential Intestinal BMP Signaling Gradient
Lymph node stromal cells: cartographers of the immune system
Integrated digital pathology and transcriptome analysis identifies molecular mediators of T-cell exclusion in ovarian cancer
Neutrophils Follow Stromal Omens to Limit Peritoneal Inflammation
A Stromal Niche Defined by Expression of the Transcription Factor WT1 Mediates Programming and Homeostasis of Cavity-Resident Macrophages
Fibroblastic reticular cells enhance T cell metabolism and survival via epigenetic remodeling
Mechanosensing by Peyer’s patch stroma regulates lymphocyte migration and mucosal antibody responses
TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells
Testosterone is an endogenous regulator of BAFF and splenic B cell number
Transcriptomic analysis of hepatocellular carcinoma reveals molecular features of disease progression and tumor immune biology
A short field guide to fibroblast function in immunity
Immunological hallmarks of stromal cells in the tumour microenvironment
The CLEC-2–podoplanin axis controls the contractility of fibroblastic reticular cells and lymph node microarchitecture