Area of research
Genetics · Rheumatology
Research interest
Research topics from publications: Asparagine reduces the risk of schizophrenia: a bidirectional two-sample mendelian randomization study of aspartate, asparagine and schizophrenia; The diagnostic potential of unconjugated bilirubin in schizophrenia and bipolar disorder. Representative work: BACKGROUND: Despite ongoing research, the underlying causes of schizophrenia remain unclear. Aspartate and asparagine, essential amino acids, have been linked to schizophrenia in recent studies, but their causal relationship is still unclear. This study used a bidirectional two-sample Mendelian randomization (MR) method to explore the causal relationship between aspartate and asparagine with schizophrenia. METHODS: This study employed summary data from genome-wide association studies (GWAS) conducted on European populations to examine the correlation between aspartate and asparagine with schizophrenia. In order to investigate the causal effects of aspartate and asparagine on schizophrenia, t BACKGROUND: Schizophrenia is not well differentiated from bipolar disorder when acute psychiatric symptoms are present. Recently, several studies have suggested a potential link between unconjugated bilirubin and schizophrenia and bipolar disorder, but the exact relationship has not been elucidated. METHODS: To compare the levels of unconjugated bilirubin in the blood of patients with schizophrenia and bipolar disorder and to analyze whether there is a potential causal relationship between unconjugated bilirubin and schizophrenia and bipolar disorder using mendelian randomization, and finally to validate the relationship between them by the clinical symptoms and the levels of unconjugated bi