Area of research
Epidemiology · Neurology
Research interest
Research topics from publications: MicroRNA-181c Exacerbates Brain Injury in Acute Ischemic Stroke; Analysis of the relationships between the degree of migraine with right-to-left shunts and changes in white matter lesions and brain structural volume. Representative work: MicroRNA-181 (miR-181) is highly expressed in the brain, and downregulated in miRNA expression profiles of acute ischemic stroke patients. However, the roles of miR-181c in stroke are not known. The clinical relevance of miR-181c in acute stroke patients was evaluated by real-time PCR and correlation analyses. Proliferation and apoptosis of BV2 microglial cells and Neuro-2a cells cultured separately or together under oxidative stress or inflammation were assessed with the Cell Counting Kit-8 and by flow cytometry, respectively. Cerebral ischemia was induced by middle cerebral artery occlusion (MCAO) in C57/BL6 mice, and cerebral infarct volume, microglia activation, and expression of pro-apo To investigate the location of white matter lesions (WMLs) in migraineurs with right‒to‒left shunts (RLS); the relationships among the severity of WMLs, changes in brain structural volume and RLS shunts; and the relationships among the severity of WMLs, changes in brain structural volume and degree of headache in RLS migraine patients. A total of 102 migraineurs with RLS admitted to the affiliated Central Hospital of Dalian University of Technology from December 2018 to December 2022 were enrolled in this study. RLS flow and the 6-item Headache Impact Test (HIT-6) scores were recorded to reflect the degree of headache. The brain structural volumes of 102 migraineurs with RLS were calculated