Area of research
Cancer Research · Molecular Biology
Research interest
Research interests include Cancer, Hypoxia, and Metabolism, Mitochondrial Function and Pathology, Epigenetics and DNA Methylation, and Metabolomics and Mass Spectrometry Studies.
Mitochondrial metabolism sustains DNMT3A-R882-mutant clonal haematopoiesis
Functional synapses between neurons and small cell lung cancer
An atlas of ferroptosis-induced secretomes
Integrated metabolomics data analysis to generate mechanistic hypotheses with MetaProViz
Publisher Correction: Functional synapses between neurons and small cell lung cancer
Chemical imaging reveals metabolite distribution in tissues using Raman microspectroscopy
Tumour sampling conditions perturb the metabolic landscape of clear cell renal cell carcinoma
Mitochondrial complex I activity in microglia sustains neuroinflammation
A glycolytic metabolite bypasses “two-hit” tumor suppression by BRCA2
Raman micro-spectroscopy reveals the spatial distribution of fumarate in cells and tissues
Fumarate induces vesicular release of mtDNA to drive innate immunity
Macrophage fumarate hydratase restrains mtRNA-mediated interferon production
A century of the Warburg effect
The role of branched-chain aminotransferase 1 in driving glioblastoma cell proliferation and invasion varies with tumor subtype
Assessment of left ventricular tissue mitochondrial bioenergetics in patients with stable coronary artery disease
Raman micro-spectroscopy reveals the spatial distribution of fumarate in cells and tissues
Control of endothelial quiescence by FOXO-regulated metabolites
Signaling metabolite L-2-hydroxyglutarate activates the transcription factor HIF-1α in lipopolysaccharide-activated macrophages
Crosstalk between mechanotransduction and metabolism
Targeting Metabolic Plasticity and Flexibility Dynamics for Cancer Therapy
Mechanism of succinate efflux upon reperfusion of the ischaemic heart
Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1
Coupling Krebs cycle metabolites to signalling in immunity and cancer
NADH Shuttling Couples Cytosolic Reductive Carboxylation of Glutamine with Glycolysis in Cells with Mitochondrial Dysfunction
Tumor pre-conditioning of draining lymph node stroma by lactic acid
High-grade ovarian serous carcinoma patients exhibit profound alterations in lipid metabolism
Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages
A Unifying Mechanism for Mitochondrial Superoxide Production during Ischemia-Reperfusion Injury
Fumarate is an epigenetic modifier that elicits epithelial-to-mesenchymal transition
A roadmap for interpreting 13C metabolite labeling patterns from cells