Area of research
Molecular Biology · Clinical Biochemistry
Research interest
Research interests include Biology, Mitochondrial DNA, Transcription (linguistics), Genetics, RNA, and TFAM.
Replication and Transcription of Human Mitochondrial DNA
Non-coding 7S RNA inhibits transcription via mitochondrial RNA polymerase dimerization
The mitochondrial single-stranded DNA binding protein is essential for initiation of mtDNA replication
POLRMT mutations impair mitochondrial transcription causing neurological disease
Small-molecule inhibitors of human mitochondrial DNA transcription
Accurate mapping of mitochondrial DNA deletions and duplications using deep sequencing
Recurrent horizontal transfer identifies mitochondrial positive selection in a transmissible cancer
TEFM regulates both transcription elongation and RNA processing in mitochondria
Dinucleotide Degradation by REXO2 Maintains Promoter Specificity in Mammalian Mitochondria
Topoisomerase 3α Is Required for Decatenation and Segregation of Human mtDNA
Maintenance and Expression of Mammalian Mitochondrial DNA
POLRMT regulates the switch between replication primer formation and gene expression of mammalian mtDNA
Regulation of DNA replication at the end of the mitochondrial D-loop involves the helicase TWINKLE and a conserved sequence element
TEFM is a potent stimulator of mitochondrial transcription elongation in vitro
The amino terminal extension of mammalian mitochondrial RNA polymerase ensures promoter specific transcription initiation
MTERF1 Binds mtDNA to Prevent Transcriptional Interference at the Light-Strand Promoter but Is Dispensable for rRNA Gene Transcription Regulation
Mammalian transcription factor A is a core component of the mitochondrial transcription machinery
A hybrid G-quadruplex structure formed between RNA and DNA explains the extraordinary stability of the mitochondrial R-loop
Structure of the human MTERF4–NSUN4 protein complex that regulates mitochondrial ribosome biogenesis
Protein sliding and DNA denaturation are essential for DNA organization by human mitochondrial transcription factor A
In vivo mutagenesis reveals that OriL is essential for mitochondrial DNA replication