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Jay D. Humphrey

Yale University · US
Area of research
Biomedical Engineering · Genetics
Research interest
Research interests include Elasticity and Material Modeling, Connective tissue disorders research, Aortic aneurysm repair treatments, and Cellular Mechanics and Interactions.
h-index
83
citations
27,690
works
642
NIH funding
primary concept
email

Recent publications

A mixed Cosserat and higher gradient formulation for fibrous tissues and biomaterials
International Journal of Solids and Structures 2026cited by 5position: contributordoi
Proximal Pulmonary Artery Stiffening as a Biomarker of Cardiopulmonary Aging.
2026cited by 1position: contributordoi
A continuum model for collective cell migration in tissues and biomaterials in response to chemo-mechanical stimuli
International Journal of Engineering Science 2026cited by 1position: contributordoi
The aorta in Marfan syndrome - from molecular mechanisms to mechanobiological dysfunction.
2026cited by 0position: contributordoi
A systematic comparison of membrane, shell, and 3D solid formulations for nonlinear vascular biomechanics
Journal of the Mechanical Behavior of Biomedical Materials 2026cited by 0position: contributordoi
The role of vascular smooth muscle cell plasticity in arterial remodelling and biomechanical failure: a numerical approach
Proceedings of the Royal Society A Mathematical Physical and Engineering Science 2026cited by 0position: contributordoi
Controlled intramural fluid injection to quantify propensity to thoracic aortic dissection
2026cited by 0position: contributordoi
Biomechanics of soft biological tissues and organs, mechanobiology, homeostasis and modelling.
2025cited by 10position: contributordoi
Short-term disruption of TGF-β signaling in adult mice renders the aorta vulnerable to hypertension-induced dissection
JCI Insight 2025cited by 5position: contributordoi
Recommendations for Design, Execution, and Reporting of Studies on Experimental Thoracic Aortopathy in Preclinical Models.
2025cited by 4position: contributordoi
Sustained tenascin-C expression drives neointimal hyperplasia and promotes aortocaval fistula failure
American Journal of Physiology-Heart and Circulatory Physiology 2025cited by 2position: middledoi
Multi-Scale Multi-Cell Computational Model of Inflammation-Mediated Aortic Remodeling in Hypertension.
2025cited by 1position: contributordoi
Sustained tenascin-C expression drives neointimal hyperplasia and promotes aortocaval fistula failure.
2025cited by 1position: contributordoi
Postnatal Pulmonary Artery Development from Transcript to Tissue
2025cited by 1position: contributordoi
Importance of localized dilatation and distensibility in identifying determinants of thoracic aortic aneurysm with neural operators.
2025cited by 0position: contributordoi
A Cross-scale Causal Mapping Framework Pinpoints Macrophage Orchestrators of Balanced Arterial Development
2025cited by 0position: contributordoi
A Systematic Comparison of Membrane, Shell, and 3D Solid Formulations for Nonlinear Vascular Biomechanics
SSRN Electronic Journal 2025cited by 0position: middledoi
Grand Challenges at the Interface of Engineering and Medicine
IEEE Open Journal of Engineering in Medicine and Biology 2024cited by 22position: middledoi
Hemodynamics and Wall Mechanics of Vascular Graft Failure.
2024cited by 21position: contributordoi
Tissue engineered vascular grafts are resistant to the formation of dystrophic calcification.
2024cited by 14position: contributordoi
Cellular stiffness sensing through talin 1 in tissue mechanical homeostasis.
2024cited by 8position: contributordoi
Grand Challenges at the Interface of Engineering and Medicine.
2024cited by 7position: contributordoi
Developmental changes in lung function of mice are independent of sex as a biological variable.
2024cited by 6position: contributordoi
Multiscale computational model of aortic remodeling following postnatal disruption of TGFβ signaling
Journal of Biomechanics 2024cited by 5position: contributordoi
A Systematic Comparison of Normal Structure and Function of the Greater Thoracic Vessels.
2024cited by 3position: contributordoi
AT1b receptors contribute to regional disparities in angiotensin II mediated aortic remodelling in mice.
2024cited by 2position: contributordoi
Dynamic biaxial loading of vascular smooth muscle cell seeded tissue equivalents
Journal of the Mechanical Behavior of Biomedical Materials 2024cited by 2position: contributordoi
Optimized Biomechanical Design of a Pulsatile Fontan Conduit for Congenital Heart Palliation
2024cited by 0position: contributordoi
A fluid–solid-growth solver for cardiovascular modeling
Computer Methods in Applied Mechanics and Engineering 2023cited by 31position: contributordoi
Homeostatic, Non-Canonical Role of Macrophage Elastase in Vascular Integrity.
2023cited by 30position: contributordoi

Grants

Chemomechanical Stimulation of Adventitial Fibroblast Remodeling of Collagen
NSF1161423$394,9562012–2015PIRePORTER
Quantification of Flow-Induced Vascular Adaptation Via an Organ Culture System
NSF0084644$302,0322001–2004PIRePORTER
Heat Induced Changes in the Mechanics of Soft Tissue
NSF9896166$171,3781998–2001PIRePORTER
Heat Induced Changes in the Mechanics of Soft Tissue
NSF9634109$158,6411996–1998PIRePORTER
Presidential Young Investigators Award - Basic Studies in Vascular Mechanics
NSF9157798$222,1141991–1996PIRePORTER

Frequent collaborators

· 90 papers (2019–2026) · 13 papers (2020–2025)Abhay B. Ramachandra · Iowa State University11 papers (2019–2026)Cristina Cavinato · Centre National de la Recherche Scientifique9 papers (2020–2026)Bruno V. Rego · Louisiana State University9 papers (2021–2023)Marcos Latorre · Universidad de Zaragoza9 papers (2019–2023)Sae‐Il Murtada · Yale University8 papers (2019–2025)Bart Spronck · Universitair Ziekenhuis Brussel8 papers (2019–2024)Yuki Kawamura · National Center for Global Health and Medicine8 papers (2020–2023)Stéphane Avril · Inserm7 papers (2018–2022)George Tellides · San Diego Cardiac Center6 papers (2021–2026)Martin A. Schwartz · Yale New Haven Hospital6 papers (2021–2025)David S. Li · University of Nebraska at Omaha6 papers (2022–2025)Matthew R. Bersi · Washington University in St. Louis6 papers (2019–2022)Chiara Bellini · Northeastern University5 papers (2013–2018)Linda Irons · 5 papers (2020–2023)Erica Schwarz · Yale University5 papers (2021–2026)C. Alberto Figueroa · University of Michigan5 papers (2012–2025)Jacopo Ferruzzi · The University of Texas at Dallas4 papers (2013–2018)George Tellides · Yale University4 papers (2014–2020)