Area of research
Molecular Biology · Pharmacology
Research interest
Research interests include Plant biochemistry and biosynthesis, Histone Deacetylase Inhibitors Research, Microbial Natural Products and Biosynthesis, and Peptidase Inhibition and Analysis.
DREDge: robust motion correction for high-density extracellular recordings across species
Aza-SAHA Derivatives Are Selective Histone Deacetylase 10 Chemical Probes That Inhibit Polyamine Deacetylation and Phenocopy HDAC10 Knockout
Identification of histone deacetylase 10 (HDAC10) inhibitors that modulate autophagy in transformed cells
First Fluorescent Acetylspermidine Deacetylation Assay for HDAC10 Identifies Selective Inhibitors with Cellular Target Engagement**
First fluorescent acetylspermidine deacetylation assay for HDAC10 identifies selective inhibitors with cellular target engagement
Identification of HDAC10 Inhibitors that Modulate Autophagy-Related Proteins in Transformed Cells
Aza-SAHA Derivatives are Selective Histone Deacetylase 10 Chemical Probes That Inhibit Polyamine Deacetylation and Phenocopy HDAC10 Knockout
Identification of HDAC10 Inhibitors that Modulate Autophagy in Transformed Cells
Harnessing the Role of HDAC6 in Idiopathic Pulmonary Fibrosis: Design, Synthesis, Structural Analysis, and Biological Evaluation of Potent Inhibitors
Aza-SAHA Derivatives are Selective Histone Deacetylase 10 Chemical Probes That Inhibit Polyamine Deacetylation
Aza-SAHA Derivatives are Selective Histone Deacetylase 10 Chemical Probes That Inhibit Polyamine Deacetylation
Structural Basis for the Selective Inhibition of HDAC10, the Cytosolic Polyamine Deacetylase
Design and Synthesis of Dihydroxamic Acids as HDAC6/8/10 Inhibitors
First Fluorescent Acetylspermidine Deacetylation Assay for HDAC10 Identifies Inhibitors of Neuroblastoma Cell Colony Growth That Increase Lysosome Accumulation
First Fluorescent Acetylspermidine Deacetylation Assay for HDAC10 Identifies Inhibitors of Neuroblastoma Cell Colony Growth That Increase Lysosome Accumulation
Entropy as a Driver of Selectivity for Inhibitor Binding to Histone Deacetylase 6
Molecular Basis for the Selective Inhibition of Histone Deacetylase 6 by a Mercaptoacetamide Inhibitor
Structural and Chemical Biology of Terpenoid Cyclases
Histone deacetylase 6 structure and molecular basis of catalysis and inhibition
Loss-of-function HDAC8 mutations cause a phenotypic spectrum of Cornelia de Lange syndrome-like features, ocular hypertelorism, large fontanelle and X-linked inheritance