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James W. Murrough

Center for Anxiety and Depression · US
Area of research
Pharmacology · Biological Psychiatry
Research interest
Research interests include Treatment of Major Depression, Tryptophan and brain disorders, Functional Brain Connectivity Studies, and Stress Responses and Cortisol.
h-index
72
citations
22,443
works
282
NIH funding
primary concept
Medicine
email

Recent publications

Major depressive disorder shares systemic immune signatures and potential therapeutic targets with inflammatory skin diseases
Molecular Psychiatry 2026cited by 2position: lastdoi
Molecular dissection of protein complexes isolated from sections of human brain
bioRxiv (Cold Spring Harbor Laboratory) 2026cited by 0position: middledoi
Spatiotemporal asymmetries on brain energy landscape uncover system entrapment related to depression severity
Nature Communications 2026cited by 0position: middledoi
Structural imaging predictors of ketamine response in treatment-resistant depression: a machine learning approach
Translational Psychiatry 2026cited by 0position: middledoi
Circulating myeloid-derived MMP8 in stress susceptibility and depression
Nature 2024cited by 147position: middledoi
Effects of vagus nerve stimulation on daily function and quality of life in markedly treatment-resistant major depression: Findings from a one-year, randomized, sham-controlled trial
Brain stimulation 2024cited by 18position: middledoi
Immune-Targeted Therapies for Depression
The Journal of Clinical Psychiatry 2024cited by 17position: lastdoi
Treatment‐resistant depression: definition, prevalence, detection, management, and investigational interventions
World Psychiatry 2023cited by 640position: middledoi
Ketamine versus ECT for Nonpsychotic Treatment-Resistant Major Depression
New England Journal of Medicine 2023cited by 244position: middledoi
Social stress induces autoimmune responses against the brain
Proceedings of the National Academy of Sciences 2023cited by 24position: middledoi
Stress-related reduction of hippocampal subfield volumes in major depressive disorder: A 7-Tesla study
Frontiers in Psychiatry 2023cited by 12position: middledoi
Peripheral immune-derived matrix metalloproteinase promotes stress susceptibility
Research Square 2023cited by 1position: lastdoi
International pooled patient-level meta-analysis of ketamine infusion for depression: In search of clinical moderators
Molecular Psychiatry 2022cited by 77position: middledoi
Beyond the neuron: Role of non-neuronal cells in stress disorders
Neuron 2022cited by 71position: middledoi
The long noncoding RNA FEDORA is a cell type– and sex-specific regulator of depression
Science Advances 2022cited by 56position: middledoi
Blood miR-144-3p: a novel diagnostic and therapeutic tool for depression
Molecular Psychiatry 2022cited by 51position: middledoi
The Potential of KCNQ Potassium Channel Openers as Novel Antidepressants
CNS Drugs 2022cited by 34position: lastdoi
Exaggerated amygdala response to threat and association with immune hyperactivity in depression
Brain Behavior and Immunity 2022cited by 30position: lastdoi
The Ketamine Side Effect Tool (KSET): A comprehensive measurement-based safety tool for ketamine treatment in psychiatry
Journal of Affective Disorders 2022cited by 19position: middledoi
Ventral tegmental area integrity measured with high-resolution 7-Tesla MRI relates to motivation across depression and anxiety diagnoses
NeuroImage 2022cited by 15position: lastdoi
Social stress induces autoimmune responses against the brain to promote stress susceptibility
bioRxiv (Cold Spring Harbor Laboratory) 2022cited by 2position: middledoi
Moral distress in frontline healthcare workers in the initial epicenter of the COVID‐19 pandemic in the United States: Relationship to PTSD symptoms, burnout, and psychosocial functioning
Depression and Anxiety 2021cited by 155position: middledoi
Peripheral immune cell reactivity and neural response to reward in patients with depression and anhedonia
Translational Psychiatry 2021cited by 86position: lastdoi
Vortioxetine Versus Placebo for Major Depressive Disorder
The Journal of Clinical Psychiatry 2021cited by 36position: middledoi
The Long Noncoding RNA FEDORA is a Cell-Type- and Sex-Specific Regulator of Depression
bioRxiv (Cold Spring Harbor Laboratory) 2021cited by 5position: middledoi
Pharmacotherapy of Anxiety Disorders: Current and Emerging Treatment Options
Frontiers in Psychiatry 2020cited by 406position: middledoi
A randomized proof-of-mechanism trial applying the ‘fast-fail’ approach to evaluating κ-opioid antagonism as a treatment for anhedonia
Nature Medicine 2020cited by 227position: middledoi
Insulin receptor substrate in brain-enriched exosomes in subjects with major depression: on the path of creation of biosignatures of central insulin resistance
Molecular Psychiatry 2020cited by 113position: middledoi
Selective kappa-opioid antagonism ameliorates anhedonic behavior: evidence from the Fast-fail Trial in Mood and Anxiety Spectrum Disorders (FAST-MAS)
Neuropsychopharmacology 2020cited by 109position: middledoi
Ketamine normalizes subgenual cingulate cortex hyper-activity in depression
Neuropsychopharmacology 2020cited by 103position: lastdoi

Grants

No grants ingested yet.

Frequent collaborators

Dan V. Iosifescu · Psychiatric Medical Center24 papers (2012–2020)Dennis S. Charney · Riverkeeper24 papers (2012–2021)Sanjay J. Mathew · Baylor College of Medicine16 papers (2012–2023)Katherine A. Collins · Icahn School of Medicine at Mount Sinai15 papers (2012–2023)Scott J. Russo · Allen Institute for Brain Science12 papers (2012–2026) · 11 papers (2017–2023)Flurin Cathomas · Allen Institute for Brain Science9 papers (2019–2026)Marin Kautz · California University of Pennsylvania7 papers (2015–2023)Andrew M. Perez · University of Central Florida7 papers (2012–2015)Eric J. Nestler · Allen Institute for Brain Science7 papers (2012–2022)Laurel Morris · University of Oxford7 papers (2018–2026)Lee C. Chang · Baylor College of Medicine6 papers (2013–2023)Michael K. Parides · Hospital for Special Surgery6 papers (2012–2021)Brian M. Iacoviello · Icahn School of Medicine at Mount Sinai6 papers (2013–2019)Laili Soleimani · Alzheimer’s Disease Neuroimaging Initiative6 papers (2014–2019)Ming‐Hu Han · Allen Institute for Brain Science5 papers (2012–2022)Kaitlin E. DeWilde · Albert Einstein College of Medicine5 papers (2015–2019)Manish K. Jha · Southwestern Medical Center5 papers (2017–2023)Diego A. Pizzagalli · Boston Medical Center5 papers (2018–2021)Adriana Feder · Icahn School of Medicine at Mount Sinai5 papers (2014–2021)