Area of research
Pharmacology · Computational Theory and Mathematics
Research interest
Research interests include Cholinesterase and Neurodegenerative Diseases, Computational Drug Discovery Methods, Pesticide Exposure and Toxicity, and Pesticide and Herbicide Environmental Studies.
Innate and adaptive immune responses to the injection of hybrid camouflaging erythrocyte Saccharolobus solfataticus-phosphotriesterase mutant-loaded nanoreactors to mice.
Kinetic and molecular modelling analyses of butyrylcholinesterase activity toward 'inverse' substrates.
New views on physiological functions and regulation of butyrylcholinesterase and potential therapeutic interventions.
Affinity Electrophoresis of Proteins for Determination of Ligand Affinity and Exploration of Binding Sites.
Kinetic analysis suggests that malathion at low environmental exposures is not toxic to humans.
Applications of Microbial Organophosphate-Degrading Enzymes to Detoxification of Organophosphorous Compounds for Medical Countermeasures against Poisoning and Environmental Remediation.
Biocatalysis: modern challenges and applications
Pharmacokinetics and fate of free and encapsulated IRD800CW-labelled human BChE intravenously administered in mice.
Human Plasma Butyrylcholinesterase Hydrolyzes Atropine: Kinetic and Molecular Modeling Studies.
Pre-Steady-State and Steady-State Kinetic Analysis of Butyrylcholinesterase-Catalyzed Hydrolysis of Mirabegron, an Arylacylamide Drug.
Polystyrene-Poly(acrylic acid) Block Copolymers for Encapsulation of Butyrylcholinesterase into Injectable Nanoreactors.
Randomized open-label controlled study of cancer vaccine OSE2101 versus chemotherapy in HLA-A2-positive patients with advanced non-small-cell lung cancer with resistance to immunotherapy: ATALANTE-1
Drug and pro-drug substrates and pseudo-substrates of human butyrylcholinesterase.
Partial Reversible Inhibition of Enzymes and Its Metabolic and Pharmaco-Toxicological Implications.
Activation/Inhibition of Cholinesterases by Excess Substrate: Interpretation of the Phenomenological <i>b</i> Factor in Steady-State Rate Equation.
Tuning the Envelope Structure of Enzyme Nanoreactors for In Vivo Detoxification of Organophosphates.
Biomedical Nanosystems for In Vivo Detoxification: From Passive Delivery Systems to Functional Nanodevices and Nanorobots.
Conformational Stability and Denaturation Processes of Proteins Investigated by Electrophoresis under Extreme Conditions.
Enzyme Nanoreactor for <i>In Vivo</i> Detoxification of Organophosphates.
Quantitative Measurements of Pharmacological and Toxicological Activity of Molecules
Kinetic Processes in Enzymatic Nanoreactors for In Vivo Detoxification.
Steady-state kinetic analysis of human cholinesterases over wide concentration ranges of competing substrates.
Organophosphorus poisoning in animals and enzymatic antidotes.
Therapeutic nanoreactors for detoxification of xenobiotics: Concepts, challenges and biotechnological trends with special emphasis to organophosphate bioscavenging.
α-tocopherol, a slow-binding inhibitor of acetylcholinesterase.
Protective effects of m-(tert-butyl) trifluoroacetophenone, a transition state analogue of acetylcholine, against paraoxon toxicity and memory impairments.
Slow-binding reversible inhibitor of acetylcholinesterase with long-lasting action for prophylaxis of organophosphate poisoning.
Slow-binding inhibitors of acetylcholinesterase of medical interest.
Impact of Sucrose as Osmolyte on Molecular Dynamics of Mouse Acetylcholinesterase.
1-(3-<i>Tert</i>-Butylphenyl)-2,2,2-Trifluoroethanone as a Potent Transition-State Analogue Slow-Binding Inhibitor of Human Acetylcholinesterase: Kinetic, MD and QM/MM Studies.