Area of research
Immunology · Immunology and Allergy
Research interest
Research interests include Mast cells and histamine, Asthma and respiratory diseases, Food Allergy and Anaphylaxis Research, and Allergic Rhinitis and Sensitization.
TNF-α counters skin inflammation by restraining mast cell–dependent thymic stromal lymphopoietin production
Mast cells express IL17A, IL17F and RORC in lesional psoriatic skin, are activated before therapy and persist in high numbers in a resting state with IL-17A positivity after treatment
MRGPRX2 ligandome: Molecular simulations reveal three categories of ligand-receptor interactions
Mast cells modulate macrophage biology through release of prestored CSF1
Prolonged <scp>IL</scp> ‐33 Exposure Switches the Secreted Mast Cell Cytokine Profile From Pro‐Inflammatory to Pro‐Tolerant
Icatibant Acts as a Balanced Ligand of MRGPRX2 in Human Skin Mast Cells
A Novel Cell Culture System to Improve MRGPRX2 Research in Human Skin Mast Cells
Cultures of Human Skin Mast Cells, an Attractive In Vitro Model for Studies of Human Mast Cell Biology
Intrinsic Regulatory Mechanisms Protect Human Skin Mast Cells from Excessive MRGPRX2 Activation: Paucity in LAD2 (Laboratory of Allergic Diseases 2) Cells Contributes to Hyperresponsiveness of the Mast Cell Line
Tolerance induction through early feeding to prevent food allergy in infants and children with sensitization against food allergens (TIFFANI): rationale, study design, and methods of a randomized controlled trial
CREB Is Critically Implicated in Skin Mast Cell Degranulation Elicited via FcεRI and MRGPRX2
<scp>IL</scp>‐1α/β and <scp>IL</scp>‐18 profiles and their impact on claudin‐1, loricrin and filaggrin expression in patients with atopic dermatitis
CREB Is Activated by the SCF/KIT Axis in a Partially ERK-Dependent Manner and Orchestrates Survival and the Induction of Immediate Early Genes in Human Skin Mast Cells
Clorfl86/RHEX Is a Negative Regulator of SCF/KIT Signaling in Human Skin Mast Cells
Synergism between IL-33 and MRGPRX2/FcεRI Is Primarily Due to the Complementation of Signaling Modules, and Only Modestly Supplemented by Prolonged Activation of Selected Kinases
CREB Is Indispensable to KIT Function in Human Skin Mast Cells—A Positive Feedback Loop between CREB and KIT Orchestrates Skin Mast Cell Fate
68 EVO756 is a novel MRGPRX2 antagonist that potently inhibits human mast cell degranulation in response to multiple agonists – potential treatment for CSU and beyond
MRGPRX2-Mediated Degranulation of Human Skin Mast Cells Requires the Operation of Gαi, Gαq, Ca++ Channels, ERK1/2 and PI3K—Interconnection between Early and Late Signaling
MRGPRX2 in drug allergy: What we know and what we do not know
FcεRI‐ and MRGPRX2‐evoked acute degranulation responses are fully additive in human skin mast cells
Mast cells instruct keratinocytes to produce thymic stromal lymphopoietin: Relevance of the tryptase/protease-activated receptor 2 axis
β-arrestin-1 and β-arrestin-2 Restrain MRGPRX2-Triggered Degranulation and ERK1/2 Activation in Human Skin Mast Cells
Serological profiling reveals hsa-miR-451a as a possible biomarker of anaphylaxis
How “Neuronal” Are Human Skin Mast Cells?
The <scp>SCF</scp>/<scp>KIT</scp> axis in human mast cells: Capicua acts as potent <scp>KIT</scp> repressor and <scp>ERK</scp> predominates <scp>PI3K</scp>
An interdisciplinary approach to characterize peanut‐allergic patients—First data from the FOOD@ consortium
Tolerance induction through early feeding to prevent food allergy in infants with eczema (TEFFA): rationale, study design, and methods of a randomized controlled trial
Tolerance induction through non-avoidance to prevent persistent food allergy (TINA) in children and adults with peanut or tree nut allergy: rationale, study design and methods of a randomized controlled trial and observational cohort study
Cytokines Stimulated by IL-33 in Human Skin Mast Cells: Involvement of NF-κB and p38 at Distinct Levels and Potent Co-Operation with FcεRI and MRGPRX2
Thymic Stromal Lymphopoietin Promotes MRGPRX2-Triggered Degranulation of Skin Mast Cells in a STAT5-Dependent Manner with Further Support from JNK