Area of research
Immunology
Research interest
Research interests include Immune Cell Function and Interaction, T-cell and B-cell Immunology, Immunodeficiency and Autoimmune Disorders, and Immune cells in cancer.
The CD58-CD2 axis is co-regulated with PD-L1 via CMTM6 and shapes anti-tumor immunity
NKG2A and HLA-E define an alternative immune checkpoint axis in bladder cancer
Comprehensive analysis of DNA replication timing across 184 cell lines suggests a role for<i>MCM10</i>in replication timing regulation
Distinct antibody responses to SARS-CoV-2 in children and adults across the COVID-19 clinical spectrum
Complex Autoinflammatory Syndrome Unveils Fundamental Principles of JAK1 Kinase Transcriptional and Biochemical Function
DNA hypermethylation during tuberculosis dampens host immune responsiveness
Notch Regulates Innate Lymphoid Cell Plasticity during Human NK Cell Development
A novel disorder involving dyshematopoiesis, inflammation, and HLH due to aberrant CDC42 function
A combined immunodeficiency with severe infections, inflammation, and allergy caused by ARPC1B deficiency
Human DEF6 deficiency underlies an immunodeficiency syndrome with systemic autoimmunity and aberrant CTLA-4 homeostasis
Genetic and mechanistic diversity in pediatric hemophagocytic lymphohistiocytosis
Heterozygous Truncating Variants in POMP Escape Nonsense-Mediated Decay and Cause a Unique Immune Dysregulatory Syndrome
Nanoscale Dynamism of Actin Enables Secretory Function in Cytolytic Cells
Genetic and Mechanistic Diversity in Hemophagocytic Lymphohistiocytosis
A Cell-Autonomous Mammalian 12 hr Clock Coordinates Metabolic and Stress Rhythms
Glycolytic requirement for NK cell cytotoxicity and cytomegalovirus control
Primary immunodeficiency diseases: Genomic approaches delineate heterogeneous Mendelian disorders
RASGRP1 deficiency causes immunodeficiency with impaired cytoskeletal dynamics
NK cells converge lytic granules to promote cytotoxicity and prevent bystander killing
Evaluation of Patients and Families With Concern for Predispositions to Hematologic Malignancies Within the Hereditary Hematologic Malignancy Clinic (HHMC)
COPA mutations impair ER-Golgi transport and cause hereditary autoimmune-mediated lung disease and arthritis
Practical NK cell phenotyping and variability in healthy adults
Early-onset lymphoproliferation and autoimmunity caused by germline STAT3 gain-of-function mutations
Cell biological steps and checkpoints in accessing NK cell cytotoxicity
Biallelic loss-of-function mutation in NIK causes a primary immunodeficiency with multifaceted aberrant lymphoid immunity
Lytic immune synapse function requires filamentous actin deconstruction by Coronin 1A
GATA2 deficiency: a protean disorder of hematopoiesis, lymphatics, and immunity
Mutations in GATA2 cause human NK cell deficiency with specific loss of the CD56bright subset
Defective actin accumulation impairs human natural killer cell function in patients with dedicator of cytokinesis 8 deficiency