Area of research
Radiology, Nuclear Medicine and Imaging · Molecular Biology
Research interest
Research interests include Monoclonal and Polyclonal Antibodies Research, Glycosylation and Glycoproteins Research, Protein purification and stability, and Blood groups and transfusion.
Putative target antigens of the stereotyped intrathecal B cell response in multiple sclerosis
Structural conservation and expanded functionality of hyper-stable human serum albumin variants
Targeting the Neonatal Fc Receptor in Autoimmune Diseases: Pipeline and Progress.
Enhanced plasma half-life and efficacy of engineered human albumin-fused GLP-1 despite enzymatic cleavage of its C-terminal end.
An intranasal subunit vaccine induces protective systemic and mucosal antibody immunity against respiratory viruses in mouse models.
Identification of a direct interaction between the Fab domains of IgG antibodies and human FcRn upon IgG-FcRn complex formation.
Engineering of anticancer human immunoglobulin A equipped with albumin for enhanced plasma half-life.
Tailored collagen binding of albumin-fused hyperactive coagulation factor IX dictates in vivo distribution and functional properties
Tailored collagen binding of albumin-fused hyperactive coagulation factor IX dictates in vivo distribution and functional properties.
Human IgG Fc-engineering for enhanced plasma half-life, mucosal distribution and killing of cancer cells and bacteria
Human IgG Fc-engineering for enhanced plasma half-life, mucosal distribution and killing of cancer cells and bacteria.
Biophysical cartography of the native and human-engineered antibody landscapes quantifies the plasticity of antibody developability.
Systematic benchmarking of mass spectrometry-based antibody sequencing reveals methodological biases
Assessing developability early in the discovery process for novel biologics.
Cytosolic antibody receptor TRIM21 is required for effective tau immunotherapy in mouse models.
Antibody blockade of Jagged1 attenuates choroidal neovascularization.
A pan-SARS-CoV-2-specific soluble angiotensin-converting enzyme 2-albumin fusion engineered for enhanced plasma half-life and needle-free mucosal delivery.
Biophysical cartography of the native and human-engineered antibody landscapes quantifies the plasticity of antibody developability
Clinical Significance of Serum Albumin and Implications of FcRn Inhibitor Treatment in IgG-Mediated Autoimmune Disorders
Progress and challenges for the machine learning-based design of fit-for-purpose monoclonal antibodies.
In silico proof of principle of machine learning-based antibody design at unconstrained scale.
Generation of Multivalent Nanobody-Based Proteins with Improved Neutralization of Long α-Neurotoxins from Elapid Snakes.
Potent TRIM21 and complement-dependent intracellular antiviral immunity requires the IgG3 hinge.
Biophysical differences in IgG1 Fc-based therapeutics relate to their cellular handling, interaction with FcRn and plasma half-life.
Prevention of Fetal/Neonatal Alloimmune Thrombocytopenia in Mice: Biochemical and Cell Biological Characterization of Isoforms of a Human Monoclonal Antibody.
Breakthrough infections with the omicron and delta variants of SARS-CoV-2 result in similar re-activation of vaccine-induced immunity
A needle-free subunit vaccine platform inducing mucosal and systemic antibody immunity
Titers of antibodies the receptor-binding domain (RBD) of ancestral SARS-CoV-2 are predictive for levels of neutralizing antibodies to multiple variants
Evaluation of the Effects of Remdesivir and Hydroxychloroquine on Viral Clearance in COVID-19 : A Randomized Trial.
Targeting the Notch Signaling Pathway in Chronic Inflammatory Diseases.