Area of research
Pulmonary and Respiratory Medicine · Epidemiology
Research interest
Our lab does basic, translational and clinical research on the role of the alveolar epithelium in the pathogenesis and resolution of acute lung injury and the acute respiratory distress syndrome. Current projects include studies of the role of cell-free hemoglobin in the pathogenesis of lung epithelial injury in acute lung injury, investigation of the role of alveolar epithelium in modulating intra-alveolar fibrin deposition in the injured lung, translational studies of biomarkers for diagnosis and prognosis in acute lung injury, and studies of donor management for lung transplantation.
A randomized trial of open lung protective ventilation compared to conventional mechanical ventilation in deceased organ donors
Acute respiratory distress syndrome
Acetaminophen for Prevention and Treatment of Organ Dysfunction in Critically Ill Patients With Sepsis
Causes and attributable fraction of death from ARDS in inflammatory phenotypes of sepsis
ESICM guidelines on acute respiratory distress syndrome: definition, phenotyping and respiratory support strategies
An integrated cell atlas of the lung in health and disease
A New Global Definition of Acute Respiratory Distress Syndrome
Identifying molecular phenotypes in sepsis: an analysis of two prospective observational cohorts and secondary analysis of two randomised controlled trials
A New Global Definition of Acute Respiratory Distress Syndrome
Exposure to ambient air pollutants and acute respiratory distress syndrome risk in sepsis
Genome-wide Association Study for AKI
Redefining critical illness
Pulse oximetry for the diagnosis and management of acute respiratory distress syndrome
Towards a biological definition of ARDS: are treatable traits the solution?
Contemporary trends in PGD incidence, outcomes, and therapies
Opportunities for improved clinical trial designs in acute respiratory distress syndrome
Upcoming and urgent challenges in critical care research based on COVID-19 pandemic experience
New Insights into Clinical and Mechanistic Heterogeneity of the Acute Respiratory Distress Syndrome: Summary of the Aspen Lung Conference 2021
Characterization of Immunopathology and Small Airway Remodeling in Constrictive Bronchiolitis
An Iron Refractory Phenotype in Obese Adipose Tissue Macrophages Leads to Adipocyte Iron Overload
Randomized Trial of Protective Lung Ventilation in Organ Donors
The Berlin definition of acute respiratory distress syndrome: should patients receiving high-flow nasal oxygen be included?
Latent class analysis-derived subphenotypes are generalisable to observational cohorts of acute respiratory distress syndrome: a prospective study
Mesenchymal stromal cells reduce evidence of lung injury in patients with ARDS
Precision medicine in acute respiratory distress syndrome: workshop report and recommendations for future research
Role of Lysocardiolipin Acyltransferase in Cigarette Smoke-Induced Lung Epithelial Cell Mitochondrial ROS, Mitochondrial Dynamics, and Apoptosis
Cortactin Modulates Lung Endothelial Apoptosis Induced by Cigarette Smoke
Risk of primary graft dysfunction following lung transplantation in selected adults with connective tissue disease-associated interstitial lung disease
Phenotypes and personalized medicine in the acute respiratory distress syndrome
Biomarkers of inflammation and repair in kidney disease progression