Area of research
Rheumatology · Oncology
Research interest
Research interests include Rheumatoid Arthritis Research and Therapies, Cytokine Signaling Pathways and Interactions, NF-κB Signaling Pathways, and Systemic Lupus Erythematosus Research.
Granzyme K activates the entire complement cascade
Progression to rheumatoid arthritis in at-risk individuals is defined by systemic inflammation and by T and B cell dysregulation
Synovial fibroblast gene expression is associated with sensory nerve growth and pain in rheumatoid arthritis
Tissue-specific enhancer–gene maps from multimodal single-cell data identify causal disease alleles
Clonal associations between lymphocyte subsets and functional states in rheumatoid arthritis synovium
The chromatin landscape of pathogenic transcriptional cell states in rheumatoid arthritis
Dysregulated <scp><i>NUB1</i></scp> and Neddylation Enhances Rheumatoid Arthritis <scp>Fibroblast‐Like</scp> Synoviocyte Inflammatory Responses
Adipocyte associated glucocorticoid signaling regulates normal fibroblast function which is lost in inflammatory arthritis
Automated multi-scale computational pathotyping (AMSCP) of inflamed synovial tissue
Mapping the dynamic genetic regulatory architecture of HLA genes at single-cell resolution
Multifaceted immune dysregulation characterizes individuals at-risk for rheumatoid arthritis
Genetic regulation of OAS1 nonsense-mediated decay underlies association with COVID-19 hospitalization in patients of European and African ancestries
Systems-biology analysis of rheumatoid arthritis fibroblast-like synoviocytes implicates cell line-specific transcription factor function
High incidence of proliferative and membranous nephritis in SLE patients with low proteinuria in the Accelerating Medicines Partnership
Genetic regulation of <i>OAS1</i> nonsense-mediated decay underlies association with risk of severe COVID-19
Notch signalling drives synovial fibroblast identity and arthritis pathology
Development of Gut-Selective Pan-Janus Kinase Inhibitor TD-1473 for Ulcerative Colitis: A Translational Medicine Programme
Synoviocyte-targeted therapy synergizes with TNF inhibition in arthritis reversal
Gastrointestinal Surgery for Inflammatory Bowel Disease Persistently Lowers Microbiome and Metabolome Diversity
Defining inflammatory cell states in rheumatoid arthritis joint synovial tissues by integrating single-cell transcriptomics and mass cytometry
Joint Location–Specific <scp>JAK</scp>‐<scp>STAT</scp> Signaling in Rheumatoid Arthritis Fibroblast‐like Synoviocytes
Comprehensive epigenetic landscape of rheumatoid arthritis fibroblast-like synoviocytes
Methods for high-dimensional analysis of cells dissociated from cryopreserved synovial tissue
Synovial tissue research: a state-of-the-art review
Regulation of the Cell Cycle and Inflammatory Arthritis by the Transcription Cofactor <i>LBH</i> Gene
Joint-specific DNA methylation and transcriptome signatures in rheumatoid arthritis identify distinct pathogenic processes
DNA Methylome Signature in Synoviocytes From Patients With Early Rheumatoid Arthritis Compared to Synoviocytes From Patients With Longstanding Rheumatoid Arthritis
Targeting phosphatase-dependent proteoglycan switch for rheumatoid arthritis therapy
An imprinted rheumatoid arthritis methylome signature reflects pathogenic phenotype
DNA methylome signature in rheumatoid arthritis