Area of research
Molecular Biology · Cellular and Molecular Neuroscience
Research interest
Research interests include Mitochondrial Function and Pathology, Genetic Neurodegenerative Diseases, Trace Elements in Health, and Mechanisms of cancer metastasis.
Mechanisms of impaired mitochondrial homeostasis and NAD+ metabolism in a model of mitochondrial heart disease exhibiting redox active iron accumulation
The Role of the Antioxidant Response in Mitochondrial Dysfunction in Degenerative Diseases: Cross-Talk between Antioxidant Defense, Autophagy, and Apoptosis
Pharmacological targeting of mitochondria in cancer stem cells: An ancient organelle at the crossroad of novel anti-cancer therapies
The metastasis suppressor, NDRG1, attenuates oncogenic TGF-β and NF-κB signaling to enhance membrane E-cadherin expression in pancreatic cancer cells
Tumor stressors induce two mechanisms of intracellular P-glycoprotein–mediated resistance that are overcome by lysosomal-targeted thiosemicarbazones
Molecular Alterations in a Mouse Cardiac Model of Friedreich Ataxia
Mitochondrial dysfunction in the neuro-degenerative and cardio-degenerative disease, Friedreich's ataxia
Roads to melanoma: Key pathways and emerging players in melanoma progression and oncogenic signaling
Copper and conquer: copper complexes of di-2-pyridylketone thiosemicarbazones as novel anti-cancer therapeutics
Redox cycling metals: Pedaling their roles in metabolism and their use in the development of novel therapeutics
Targeting the Metastasis Suppressor, N-Myc Downstream Regulated Gene-1, with Novel Di-2-Pyridylketone Thiosemicarbazones: Suppression of Tumor Cell Migration and Cell-Collagen Adhesion by Inhibiting Focal Adhesion Kinase/Paxillin Signaling
Frataxin and the molecular mechanism of mitochondrial iron-loading in Friedreich's ataxia
Cellular iron uptake, trafficking and metabolism: Key molecules and mechanisms and their roles in disease
The proto-oncogene c-Src and its downstream signaling pathways are inhibited by the metastasis suppressor, NDRG1
The molecular effect of metastasis suppressors on Src signaling and tumorigenesis: new therapeutic targets
The role of NDRG1 in the pathology and potential treatment of human cancers
Molecular and Functional Alterations in a Mouse Cardiac Model of Friedreich Ataxia
Fixing frataxin: ‘ironing out’ the metabolic defect in <scp>F</scp>riedreich's ataxia
Identification of nonferritin mitochondrial iron deposits in a mouse model of Friedreich ataxia