Area of research
Molecular Biology · Pharmacology
Research interest
Research interests include DNA and Nucleic Acid Chemistry, Advanced biosensing and bioanalysis techniques, RNA Interference and Gene Delivery, and Cancer therapeutics and mechanisms.
HSP72 interacts with PRDX6 to deubiquitinate mitochondrial PINK1, activating mitophagy to treat MASLD.
An Orally Available Telomeric G-Quadruplex Ligand Induces Telomere Crisis and Dual DNA/RNA-Sensing Innate Immunity for Cancer Therapy.
A novel NAMPT activator ameliorates obesity by repressing ACSL1-dependent lipid synthesis
Recent Progress and Potential of G4 Ligands in Cancer Immunotherapy.
L-aspartate ameliorates diet-induced obesity by increasing adipocyte energy expenditure.
Development of a Fluorescent Probe for Specific Visualization of Intracellular DNA i-Motif Participating in Key Biological Function.
An Aggregation/Monomer-Based Probe for Monitoring Mitochondria-Lysosome Interactions during Cuproptosis.
Identification of Indoquinazoline Derivatives as Novel NR4A1 Agonists by Suppressing Adipocyte Lipogenesis for Treatment of Obesity.
Deciphering Phase-Separated Mitochondrial RNA Granules under Stress Conditions with the Mitoribosome-Targeting Small Molecule.
N-Halosuccinimide enables cascade oxidative trifluorination and halogenative cyclization of tryptamine-derived isocyanides
Discovery of Novel Coumarin-quinolinium Derivatives as Pan-KRAS Translation Inhibitors by Targeting 5′-UTR RNA G-Quadruplexes
Discovery of Novel Coumarin-quinolinium Derivatives as Pan-KRAS Translation Inhibitors by Targeting 5'-UTR RNA G-Quadruplexes.
N-Halosuccinimide enables cascade oxidative trifluorination and halogenative cyclization of tryptamine-derived isocyanides.
Development of Novel <i>N</i>-Acylhydrazone Derivatives with High Anti-obesity Activity and Improved Safety by Exploring the Pharmaceutical Properties of Aldehyde Group.
Revealing Mitochondrion–Lysosome Dynamic Interactions and pH Variations in Live Cells with a pH-Sensitive Fluorescent Probe
Revealing Mitochondrion-Lysosome Dynamic Interactions and pH Variations in Live Cells with a pH-Sensitive Fluorescent Probe.
Development and Characterization of Benzoselenazole Derivatives as Potent and Selective <i>c-MYC</i> Transcription Inhibitors.
Construction of a TICT-AIE-Integrated Unimolecular Platform for Imaging Lipid Droplet-Mitochondrion Interactions in Live Cells and <i>In Vivo</i>.
Design and Synthesis of Bouchardatine Derivatives as a Novel AMP-Activated Protein Kinase Activator for the Treatment of Colorectal Cancer.
Discovery of the First Raptor (Regulatory-Associated Protein of mTOR) Inhibitor as a New Type of Antiadipogenic Agent.
Discovery of Clinically Used Octenidine as <i>NRAS</i> Repressor That Effectively Inhibits <i>NRAS</i>-Mutant Melanoma.
Fluorescent Quinolinium Derivative as Novel Mitochondria Probe and Function Modulator by Targeting Mitochondrial RNA.
Discovery of Ingenane Diterpenoids from <i>Euphorbia hylonoma</i> as Antiadipogenic Agents.
A rapid and highly sensitive immunosorbent assay to monitor helicases unwinding diverse nucleic acid structures
MSN8C: A Promising Candidate for Antitumor Applications as a Novel Catalytic Inhibitor of Topoisomerase II.
Construction of a TICT-AIE-Integrated Unimolecular Platform for Imaging Lipid Droplet–Mitochondrion Interactions in Live Cells and <i>In Vivo</i>
Visualization of ligand-induced <i>c-MYC</i> duplex–quadruplex transition and direct exploration of the altered <i>c-MYC</i> DNA-protein interactions in cells
Matrine counteracts obesity in mice via inducing adipose thermogenesis by activating HSF1/PGC-1α axis
A novel HSF1 activator ameliorates non-alcoholic steatohepatitis by stimulating mitochondrial adaptive oxidation.
Discovery of a Novel G-Quadruplex and Histone Deacetylase (HDAC) Dual-Targeting Agent for the Treatment of Triple-Negative Breast Cancer.