Area of research
Molecular Biology · Cancer Research
Research interest
Research interests include Mitochondrial Function and Pathology, Cancer, Hypoxia, and Metabolism, Epigenetics and DNA Methylation, and Histone Deacetylase Inhibitors Research.
Protective and pathogenic: The Janus-faced role of cGAS-STING in the brain.
Ironing out mechanisms of ferroptotic death to tailor new stroke therapies.
Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism
Alzheimer’s disease-linked risk alleles elevate microglial cGAS-associated senescence and neurodegeneration in a tauopathy model
Selenium abandons selenoproteins to inhibit ferroptosis rapidly.
Tau activation of microglial cGAS–IFN reduces MEF2C-mediated cognitive resilience
2-Deoxyglucose drives plasticity via an adaptive ER stress-ATF4 pathway and elicits stroke recovery and Alzheimer’s resilience
Hemin-Induced Death Models Hemorrhagic Stroke and Is a Variant of Classical Neuronal Ferroptosis
Hemin-Induced Death Models Hemorrhagic Stroke and Is a Variant of Classical Neuronal Ferroptosis.
Longitudinal transcriptomics define the stages of myeloid activation in the living human brain after intracerebral hemorrhage
HIF1α stabilization in hypoxia is not oxidant-initiated
HIF1α stabilization in hypoxia is not oxidant-initiated.
Author response: HIF1α stabilization in hypoxia is not oxidant-initiated
The Chemical Biology of Ferroptosis in the Central Nervous System
The drug adaptaquin blocks ATF4/CHOP-dependent pro-death Trib3 induction and protects in cellular and mouse models of Parkinson's disease
Machine intelligence identifies soluble TNFa as a therapeutic target for spinal cord injury
Selenium Drives a Transcriptional Adaptive Program to Block Ferroptosis and Treat Stroke
Ferroptosis in Neurons and Cancer Cells Is Similar But Differentially Regulated by Histone Deacetylase Inhibitors
Ferroptosis in Neurons and Cancer Cells Is Similar But Differentially Regulated by Histone Deacetylase Inhibitors.
N‐acetylcysteine targets 5 lipoxygenase‐derived, toxic lipids and can synergize with prostaglandin E <sub>2</sub> to inhibit ferroptosis and improve outcomes following hemorrhagic stroke in mice
Activation of Nrf2 and Hypoxic Adaptive Response Contribute to Neuroprotection Elicited by Phenylhydroxamic Acid Selective HDAC6 Inhibitors
Neuronal Death After Hemorrhagic Stroke In Vitro and In Vivo Shares Features of Ferroptosis and Necroptosis
Exercise promotes the expression of brain derived neurotrophic factor (BDNF) through the action of the ketone body β-hydroxybutyrate
Butyrate, neuroepigenetics and the gut microbiome: Can a high fiber diet improve brain health?
Oxidative Stress and Huntington’s Disease: The Good, The Bad, and The Ugly
Distinct Nrf2 Signaling Mechanisms of Fumaric Acid Esters and Their Role in Neuroprotection against 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Induced Experimental Parkinson's-Like Disease
Therapeutic targeting of oxygen-sensing prolyl hydroxylases abrogates ATF4-dependent neuronal death and improves outcomes after brain hemorrhage in several rodent models
Bioactive Flavonoids and Catechols as Hif1 and Nrf2 Protein Stabilizers - Implications for Parkinson’s Disease
Recent advances in hydrogen peroxide imaging for biological applications
A Selective Phenelzine Analogue Inhibitor of Histone Demethylase LSD1