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David A. Dean

University of Rochester Medical Center · US
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Area of research
Molecular Biology · Parasitology
Research interest
Research interests include RNA Interference and Gene Delivery, Parasites and Host Interactions, Parasite Biology and Host Interactions, and Virus-based gene therapy research.
h-index
65
citations
17,474
works
452
NIH funding
primary concept
email

Recent publications

Anticodon-edited transfer RNAs (ACE-tRNAs) encoded as therapeutic nonviral minimal DNA vectors.
2026cited by 1position: contributordoi
Ki-67 promotes inflammatory signaling governing neutrophil recruitment during respiratory infections.
2025cited by 0position: contributordoi
Subnuclear organization and mislocalization of plasmids reduce transgene expression
Molecular Therapy Nucleic Acids 2025cited by 0position: contributordoi
MTOR maintains endothelial cell integrity to limit lung vascular injury.
2024cited by 1position: contributordoi
Spleen Tyrosine Kinase phosphorylates VE-cadherin to cause endothelial barrier disruption in acute lung injury.
2023cited by 5position: contributordoi
Impact of Peptide Sequence on Functional siRNA Delivery and Gene Knockdown with Cyclic Amphipathic Peptide Delivery Agents.
2023cited by 4position: contributordoi
Multiple conductance states of lipid pores during Voltage-Clamp electroporation.
2023cited by 1position: contributordoi
Pulmonary gene delivery-Realities and possibilities.
2021cited by 11position: contributordoi
The Na+, K+-ATPase β1 subunit regulates epithelial tight junctions via MRCKα.
2021cited by 10position: contributordoi
Changes in lung immune cell infiltrates after electric field treatment in mice.
2021cited by 5position: contributordoi
Synthesis and Application of Peptide-siRNA Nanoparticles from Disulfide-Constrained Cyclic Amphipathic Peptides for the Functional Delivery of Therapeutic Oligonucleotides to the Lung.
2021cited by 3position: contributordoi
In vivo rescue of recombinant Zika virus from an infectious cDNA clone and its implications in vaccine development.
2020cited by 19position: contributordoi
Disruption of normal patterns of FOXF1 expression in a lethal disorder of lung development.
2020cited by 8position: contributordoi
A Fully Magnetically Levitated Left Ventricular Assist Device — Final Report
New England Journal of Medicine 2019cited by 1,238position: middledoi
Caveolin-1 gene therapy inhibits inflammasome activation to protect from bleomycin-induced pulmonary fibrosis.
2019cited by 31position: contributordoi
Critical role of autophagy regulator Beclin1 in endothelial cell inflammation and barrier disruption.
2019cited by 29position: contributordoi
RNAi therapeutic strategies for acute respiratory distress syndrome.
2019cited by 17position: contributordoi
Two-Year Outcomes with a Magnetically Levitated Cardiac Pump in Heart Failure
New England Journal of Medicine 2018cited by 706position: middledoi
A Fully Magnetically Levitated Circulatory Pump for Advanced Heart Failure
New England Journal of Medicine 2016cited by 739position: middledoi
IL-13 Induces YY1 through the AKT Pathway in Lung Fibroblasts
PLoS ONE 2015cited by 27position: middledoi
SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice
Journal of Clinical Investigation 2012cited by 349position: middledoi
EARLY AIRWAY PRESSURE RELEASE VENTILATION PREVENTS ARDS—A NOVEL PREVENTIVE APPROACH TO LUNG INJURY
Shock 2012cited by 129position: middledoi

Grants

CMG RESEARCH: Numerical and Experimental Validation of Stochastic Upscaling for Subsurface Contamination Problems Involving Multiphase Volatile Chlorinated Solvents
NSF0222286$310,0002002–2007PIRePORTER
CMG RESEARCH: Numerical and Experimental Validation of Stochastic Upscaling for Subsurface Contamination Problems Involving Multiphase Volatile Chlorinated Solvents
NSF0222300$309,9812002–2006PIRePORTER
Florida Regional Cooperative Computing Activity
NSF7203677$29,0001972–1975PIRePORTER

Frequent collaborators

· 9 papers (2021–2026)Hongwei Yao · Brown University2 papers (2012–2015)Xin Lin · Howard Hughes Medical Institute2 papers (2012–2015)Uday K Baliga · Colorado State University2 papers (2021–2023)Arshad Rahman · National Heart Lung and Blood Institute2 papers (2023–2025)Ulrich P. Jorde · Montefiore Medical Center1 papers (2016–2016) · 1 papers (2012–2012) · 1 papers (2012–2012) · 1 papers (2012–2012)Michael W. McBurney · University of Manchester1 papers (2012–2012) · 1 papers (2012–2012)Kelly McCants · University of Louisville1 papers (2016–2016)Zhou Zhu · Brown University1 papers (2015–2015)Mary Norine Walsh · Brigham and Women's Hospital1 papers (2016–2016) · 1 papers (2012–2012)Francis D. Pagani · University of Michigan1 papers (2016–2016)Sangwoon Chung · University of Illinois Chicago1 papers (2012–2012)Mandeep R. Mehra · Harvard University1 papers (2016–2016)Irfan Rahman · University of Rochester Medical Center1 papers (2012–2012)Akinobu Itoh · Brigham and Women's Hospital1 papers (2016–2016)
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