Area of research
Surgery · Oncology
Research interest
Research interests include Pancreatitis Pathology and Treatment, Pancreatic and Hepatic Oncology Research, Pancreatic function and diabetes, and Phagocytosis and Immune Regulation.
Perspective on alcohol-induced organ damage via autophagy-dependent cellular changes
Trypsin in pancreatitis: The culprit, a mediator, or epiphenomenon?
Dysregulation of mannose-6-phosphate–dependent cholesterol homeostasis in acinar cells mediates pancreatitis
Critical thresholds: key to unlocking the door to the prevention and specific treatments for acute pancreatitis
Transgenic expression of GFP-LC3 perturbs autophagy in exocrine pancreas and acute pancreatitis responses in mice
Acute Pancreatitis: A Multifaceted Set of Organelle and Cellular Interactions
Impaired TFEB-mediated lysosomal biogenesis promotes the development of pancreatitis in mice and is associated with human pancreatitis
Early trypsin activation develops independently of autophagy in caerulein-induced pancreatitis in mice
Cathepsin B-Mediated Activation of Trypsinogen in Endocytosing Macrophages Increases Severity of Pancreatitis in Mice
Accelerating the Drug Delivery Pipeline for Acute and Chronic Pancreatitis
Mitochondrial Dysfunction, Through Impaired Autophagy, Leads to Endoplasmic Reticulum Stress, Deregulated Lipid Metabolism, and Pancreatitis in Animal Models
Autophagy, Inflammation, and Immune Dysfunction in the Pathogenesis of Pancreatitis
Incidence of pancreatic cancer is dramatically increased by a high fat, high calorie diet in KrasG12D mice
Human Pancreatic Acinar Cells
Roles of autophagy and metabolism in pancreatic cancer cell adaptation to environmental challenges
Experimental approach to determine the effects of diet, alcohol and smoking on pancreatic carcinogenesis
Mechanism of mitochondrial permeability transition pore induction and damage in the pancreas: inhibition prevents acute pancreatitis by protecting production of ATP
Lysosome-Associated Membrane Proteins (LAMP) Maintain Pancreatic Acinar Cell Homeostasis: LAMP-2–Deficient Mice Develop Pancreatitis
Inflammation, Autophagy, and Obesity: Common Features in the Pathogenesis of Pancreatitis and Pancreatic Cancer
Loss of acinar cell IKKα triggers spontaneous pancreatitis in mice
Autophagy and pancreatitis
Effects of Oxidative Alcohol Metabolism on the Mitochondrial Permeability Transition Pore and Necrosis in a Mouse Model of Alcoholic Pancreatitis
The burning question: Why is smoking a risk factor for pancreatic cancer?
Protein Kinase D Regulates Cell Death Pathways in Experimental Pancreatitis