Area of research
Molecular Biology · Cellular and Molecular Neuroscience
Research interest
Research interests include Retinal Development and Disorders, Photoreceptor and optogenetics research, Virus-based gene therapy research, and CRISPR and Genetic Engineering.
Ocular gene therapy mediated by AAV vectors: an overview of immunosuppressive treatments and immunomonitoring of patients involved in clinical trials
Impact of DNase digestion on titer measurements of engineered adeno-associated virus serotypes.
Ectopic expression of two cone opsins in mouse RGCs results in opposite responses to light stimulation, likely due to differential G protein activation
Reactivating the phototransduction cascade with a mutation agnostic gene therapy preserves vision in rod-cone dystrophies
AAV-delivered CRISPR-Cas9 elicits persistent retinal immune responses compared with transient responses to RNP
Characterization of anti-AAV2 neutralizing antibody levels in sheep prior to and following intravitreal AAV2.7m8 injection
Characterization of anti-AAV2 neutralizing antibody levels in sheep prior to and following intravitreal AAV2.7m8 injection.
The Role of Thermal Stability in AAV Titration of Engineered Variants
Optimal sequencing depth for measuring the concentrations of molecular barcodes
Inducible nonhuman primate models of retinal degeneration for testing end-stage therapies.
ACIDES: on-line monitoring of forward genetic screens for protein engineering.
Cellular Immune Responses Induced by Subretinal AAV Gene Transfer can be Restrained by the Subretinal Associated Immune Inhibition Mechanism
Uncursing winner’s curse: on-line monitoring of directed evolution convergence
Early and late stage gene therapy interventions for inherited retinal degenerations.
Systemic and local immune responses to intraocular AAV vector administration in non-human primates.
Numb regulates Tau levels and prevents neurodegeneration in tauopathy mouse models.
Outer retinal transduction by AAV2-7m8 following intravitreal injection in a sheep model of CNGA3 achromatopsia.
Reactivating the phototransduction cascade by universally applicable gene therapy preserves retinal function in Rod-Cone dystrophy
Partial recovery of visual function in a blind patient after optogenetic therapy
Partial recovery of visual function in a blind patient after optogenetic therapy.
Optogenetic therapy: high spatiotemporal resolution and pattern discrimination compatible with vision restoration in non-human primates
Optogenetic therapy: high spatiotemporal resolution and pattern discrimination compatible with vision restoration in non-human primates.
Chronic nicotine increases midbrain dopamine neuron activity and biases individual strategies towards reduced exploration in mice.
Outer retinal transduction by AAV2-7m8 following intravitreal injection in a sheep model of CNGA3 achromatopsia
Functional ultrasound imaging of the spreading activity following optogenetic stimulation of the rat visual cortex
Chronic nicotine increases midbrain dopamine neuron activity and biases individual strategies towards reduced exploration in a foraging task
Neural circuits in the mouse retina support color vision in the upper visual field.
Advancing Clinical Trials for Inherited Retinal Diseases: Recommendations from the Second Monaciano Symposium
In vivo-directed evolution of adeno-associated virus in the primate retina.
Advancing Clinical Trials for Inherited Retinal Diseases: Recommendations from the Second Monaciano Symposium.