Area of research
Molecular Biology · Materials Chemistry
Research interest
Research interests include Enzyme Structure and Function, Protein Structure and Dynamics, Microbial Metabolic Engineering and Bioproduction, and Bioinformatics and Genomic Networks.
Exploring the sequence, function, and evolutionary space of protein superfamilies using sequence similarity networks and phylogenetic reconstructions
Effusion: prediction of protein function from sequence similarity networks.
InterPro in 2019: improving coverage, classification and access to protein sequence annotations
Atlas of the Radical SAM Superfamily: Divergent Evolution of Function Using a “Plug and Play” Domain
Revealing Unexplored Sequence-Function Space Using Sequence Similarity Networks
Evolutionary and molecular foundations of multiple contemporary functions of the nitroreductase superfamily
InterPro in 2017—beyond protein family and domain annotations
Molecular Diversity of Terpene Synthases in the Liverwort Marchantia polymorpha
[FeFe]-Hydrogenase Maturation: Insights into the Role HydE Plays in Dithiomethylamine Biosynthesis
Determinants of the CmoB carboxymethyl transferase utilized for selective tRNA wobble modification
Prediction and characterization of enzymatic activities guided by sequence similarity and genome neighborhood networks
Large-Scale Determination of Sequence, Structure, and Function Relationships in Cytosolic Glutathione Transferases across the Biosphere
New Insights about Enzyme Evolution from Large Scale Studies of Sequence and Structure Relationships
Predicting the Functions and Specificity of Triterpenoid Synthases: A Mechanism-Based Multi-intermediate Docking Approach
Mechanistic and Bioinformatic Investigation of a Conserved Active Site Helix in α-Isopropylmalate Synthase from <i>Mycobacterium tuberculosis</i>, a Member of the DRE-TIM Metallolyase Superfamily
A large-scale evaluation of computational protein function prediction
The Structure–Function Linkage Database
Discovery of new enzymes and metabolic pathways by using structure and genome context
Biases in the Experimental Annotations of Protein Function and Their Effect on Our Understanding of Protein Function Space
Structure-guided discovery of the metabolite carboxy-SAM that modulates tRNA function
Prediction of function for the polyprenyl transferase subgroup in the isoprenoid synthase superfamily
Consequences of domain insertion on sequence-structure divergence in a superfold
Conservation of caspase substrates across metazoans suggests hierarchical importance of signaling pathways over specific targets and cleavage site motifs in apoptosis